Drug interactions
Colestipol + Hydrochlorothiazide
Severity: Moderate
Colestipol and Hydrochlorothiazide: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Colestipol binds hydrochlorothiazide in the gut and markedly reduces how much is absorbed when both are taken orally together. This can weaken the diuretic and antihypertensive effect.
What this interaction means in plain words
Colestipol and Hydrochlorothiazide can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Colestipol belongs to Cardiovascular; Hydrochlorothiazide belongs to Cardiovascular.
Why it happens
Anion-exchange resin adsorbs hydrochlorothiazide in the gastrointestinal tract, reducing absorption.
What to do
Give hydrochlorothiazide at least 1 hour before or 4 hours after colestipol, and monitor blood pressure and edema control.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Hydrochlorothiazide
Other interactions of Colestipol
- Amlodipine-hydrochlorothiazide-valsartan + Colestipol Moderate
- Amlodipine-olmesartan-hydrochlorothiazide + Colestipol Moderate
- Atenolol-chlorthalidone + Colestipol Moderate
- Azilsartan-chlorthalidone + Colestipol Moderate
- Candesartan-hydrochlorothiazide + Colestipol Moderate
- Captopril-hydrochlorothiazide + Colestipol Moderate
Frequently asked questions
Can I take Colestipol with Hydrochlorothiazide?
MediHelp rates the interaction as moderate. Colestipol and Hydrochlorothiazide can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Colestipol binds hydrochlorothiazide in the gut and markedly reduces how much is absorbed when both are taken orally together. This can weaken the diuretic and antihypertensive effect.
How serious is the interaction between Colestipol and Hydrochlorothiazide?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Give hydrochlorothiazide at least 1 hour before or 4 hours after colestipol, and monitor blood pressure and edema control.
What other medicines interact with Hydrochlorothiazide?
MediHelp also lists interactions of Hydrochlorothiazide with, for example, Dofetilide, Amifostine, Amiodarone. The full list is on the Hydrochlorothiazide page.
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