Drug interactions
Colestipol + Methylprednisolone
Severity: Moderate
Colestipol and Methylprednisolone: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Colestipol is a bile acid sequestrant that can bind oral corticosteroids in the gut and reduce their absorption. This may lower methylprednisolone exposure and weaken its anti-inflammatory or immunosuppressive effect.
What this interaction means in plain words
Colestipol and Methylprednisolone can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Colestipol belongs to Cardiovascular; Methylprednisolone belongs to Endocrine.
Why it happens
Binding of oral methylprednisolone in the gastrointestinal tract by the resin, decreasing absorption.
What to do
Give oral methylprednisolone at least 1 hour before or 4 hours after colestipol. Watch for reduced steroid response and adjust dose if needed.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Methylprednisolone
- Bcg vaccine live + Methylprednisolone Contraindicated
- Measles mumps and rubella vaccine live + Methylprednisolone Contraindicated
- Measles mumps rubella and varicella vaccine live + Methylprednisolone Contraindicated
- Measles vaccine + Methylprednisolone Contraindicated
- Methylprednisolone + Mifepristone Contraindicated
- Methylprednisolone + Rubella vaccine Contraindicated
Other interactions of Colestipol
- Amlodipine-hydrochlorothiazide-valsartan + Colestipol Moderate
- Amlodipine-olmesartan-hydrochlorothiazide + Colestipol Moderate
- Atenolol-chlorthalidone + Colestipol Moderate
- Azilsartan-chlorthalidone + Colestipol Moderate
- Candesartan-hydrochlorothiazide + Colestipol Moderate
- Captopril-hydrochlorothiazide + Colestipol Moderate
Frequently asked questions
Can I take Colestipol with Methylprednisolone?
MediHelp rates the interaction as moderate. Colestipol and Methylprednisolone can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Colestipol is a bile acid sequestrant that can bind oral corticosteroids in the gut and reduce their absorption. This may lower methylprednisolone exposure and weaken its anti-inflammatory or immunosuppressive effect.
How serious is the interaction between Colestipol and Methylprednisolone?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Give oral methylprednisolone at least 1 hour before or 4 hours after colestipol. Watch for reduced steroid response and adjust dose if needed.
What other medicines interact with Methylprednisolone?
MediHelp also lists interactions of Methylprednisolone with, for example, Bcg vaccine live, Measles mumps and rubella vaccine live, Measles mumps rubella and varicella vaccine live. The full list is on the Methylprednisolone page.
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