Drug interactions
Colestipol + Metolazone
Severity: Moderate
Colestipol and Metolazone: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Colestipol is an anion-exchange resin that can bind oral thiazide-type diuretics in the gut and reduce their absorption. This may blunt the diuretic effect of metolazone when both are taken together.
What this interaction means in plain words
Colestipol and Metolazone can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Colestipol belongs to Cardiovascular; Metolazone belongs to Cardiovascular.
Why it happens
Colestipol binds metolazone in the gastrointestinal tract, reducing its absorption.
What to do
Give metolazone at least 1 hour before or 4 hours after colestipol. Monitor diuretic response and blood pressure.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Metolazone
Other interactions of Colestipol
- Amlodipine-hydrochlorothiazide-valsartan + Colestipol Moderate
- Amlodipine-olmesartan-hydrochlorothiazide + Colestipol Moderate
- Atenolol-chlorthalidone + Colestipol Moderate
- Azilsartan-chlorthalidone + Colestipol Moderate
- Candesartan-hydrochlorothiazide + Colestipol Moderate
- Captopril-hydrochlorothiazide + Colestipol Moderate
Frequently asked questions
Can I take Colestipol with Metolazone?
MediHelp rates the interaction as moderate. Colestipol and Metolazone can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Colestipol is an anion-exchange resin that can bind oral thiazide-type diuretics in the gut and reduce their absorption. This may blunt the diuretic effect of metolazone when both are taken together.
How serious is the interaction between Colestipol and Metolazone?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Give metolazone at least 1 hour before or 4 hours after colestipol. Monitor diuretic response and blood pressure.
What other medicines interact with Metolazone?
MediHelp also lists interactions of Metolazone with, for example, Amifostine, Amlodipine-hydrochlorothiazide-valsartan, Amlodipine-olmesartan-hydrochlorothiazide. The full list is on the Metolazone page.
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