Drug interactions
Colestipol + Pravastatin
Severity: Minor
Colestipol and Pravastatin: minor interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Colestipol can bind pravastatin in the gut and lower its absorption, which may reduce its lipid-lowering effect. Taken together the two drugs are also commonly combined for additive LDL lowering.
What this interaction means in plain words
Colestipol and Pravastatin have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised.
Colestipol belongs to Cardiovascular; Pravastatin belongs to Cardiovascular.
Why it happens
Bile acid sequestrant binds pravastatin in the gastrointestinal tract, reducing absorption.
What to do
Give pravastatin at least 1 hour before or 4 hours after colestipol. Monitor the lipid profile.
What to ask your pharmacist
- Is there anything I should notice while taking both?
- Do I need to tell my doctor at the next visit?
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Other interactions of Pravastatin
Other interactions of Colestipol
- Amlodipine-hydrochlorothiazide-valsartan + Colestipol Moderate
- Amlodipine-olmesartan-hydrochlorothiazide + Colestipol Moderate
- Atenolol-chlorthalidone + Colestipol Moderate
- Azilsartan-chlorthalidone + Colestipol Moderate
- Candesartan-hydrochlorothiazide + Colestipol Moderate
- Captopril-hydrochlorothiazide + Colestipol Moderate
Frequently asked questions
Can I take Colestipol with Pravastatin?
MediHelp rates the interaction as minor. Colestipol and Pravastatin have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised. Colestipol can bind pravastatin in the gut and lower its absorption, which may reduce its lipid-lowering effect. Taken together the two drugs are also commonly combined for additive LDL lowering.
How serious is the interaction between Colestipol and Pravastatin?
MediHelp rates it minor, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Give pravastatin at least 1 hour before or 4 hours after colestipol. Monitor the lipid profile.
What other medicines interact with Pravastatin?
MediHelp also lists interactions of Pravastatin with, for example, Cyclosporin, Gemfibrozil, Ombitasvir / paritaprevir / ritonavir and dasabuvir. The full list is on the Pravastatin page.
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