Drug interactions
Ketoconazole + Silodosin
Severity: Contraindicated
Ketoconazole and Silodosin: contraindicated interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Ketoconazole markedly raises silodosin exposure, increasing the risk of orthostatic hypotension, syncope and other dose-related adverse effects. Silodosin labeling contraindicates use with strong CYP3A4 inhibitors.
What this interaction means in plain words
Ketoconazole and Silodosin are not normally used together. Taking them at the same time is expected to cause harm or make one of them unsafe, so a different medicine is usually chosen for one of the two.
Ketoconazole belongs to Anti Fungals; Silodosin belongs to Genitourinary.
Why it happens
Strong inhibition of CYP3A4 and P-glycoprotein reduces silodosin clearance and increases its absorption.
What to do
Do not coadminister; choose an alternative alpha-blocker or antifungal. If the antifungal is essential, hold silodosin during treatment.
What to ask your pharmacist
- Is there an alternative to one of these two medicines for me?
- If both are essential, who is monitoring me and how often?
- Which symptoms mean I should stop and seek help straight away?
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Other interactions of Silodosin
- Atazanavir + Silodosin Contraindicated
- Conivaptan + Silodosin Contraindicated
- Darunavir + Silodosin Contraindicated
- Fosamprenavir + Silodosin Contraindicated
- Indinavir + Silodosin Contraindicated
- Itraconazole + Silodosin Contraindicated
Other interactions of Ketoconazole
- Alfuzosin + Ketoconazole Contraindicated
- Alprazolam + Ketoconazole Contraindicated
- Avanafil + Ketoconazole Contraindicated
- Conivaptan + Ketoconazole Contraindicated
- Dihydroergotamine intranasal + Ketoconazole Contraindicated
- Dihydroergotamine + Ketoconazole Contraindicated
Frequently asked questions
Can I take Ketoconazole with Silodosin?
MediHelp rates the interaction as contraindicated. Ketoconazole and Silodosin are not normally used together. Taking them at the same time is expected to cause harm or make one of them unsafe, so a different medicine is usually chosen for one of the two. Ketoconazole markedly raises silodosin exposure, increasing the risk of orthostatic hypotension, syncope and other dose-related adverse effects. Silodosin labeling contraindicates use with strong CYP3A4 inhibitors.
How serious is the interaction between Ketoconazole and Silodosin?
MediHelp rates it contraindicated, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Do not coadminister; choose an alternative alpha-blocker or antifungal. If the antifungal is essential, hold silodosin during treatment.
What other medicines interact with Silodosin?
MediHelp also lists interactions of Silodosin with, for example, Atazanavir, Conivaptan, Darunavir. The full list is on the Silodosin page.
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