Drug interactions
Conjugated estrogens + Fosfomycin
Severity: Minor
Conjugated estrogens and Fosfomycin: minor interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Antibiotics are theorized to reduce oral estrogen exposure by altering gut flora that deconjugate estrogens for reabsorption. Clinical evidence for fosfomycin is lacking and a meaningful effect is unlikely.
What this interaction means in plain words
Conjugated estrogens and Fosfomycin have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised.
Why it happens
Theoretical reduction in enterohepatic recirculation of estrogens due to altered intestinal flora.
What to do
No routine change is needed. Ask the patient to report breakthrough bleeding or symptom recurrence.
What to ask your pharmacist
- Is there anything I should notice while taking both?
- Do I need to tell my doctor at the next visit?
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Other interactions of Fosfomycin
- Cholera vaccine + Fosfomycin Moderate
- Fosfomycin + Metoclopramide Moderate
- Fosfomycin + Metoclopramide intranasal Moderate
- Fosfomycin + Microbiota Moderate
- Fosfomycin + Typhoid vaccine live Moderate
- Bazedoxifene / conjugated estrogens + Fosfomycin Minor
Frequently asked questions
Can I take Conjugated estrogens with Fosfomycin?
MediHelp rates the interaction as minor. Conjugated estrogens and Fosfomycin have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised. Antibiotics are theorized to reduce oral estrogen exposure by altering gut flora that deconjugate estrogens for reabsorption. Clinical evidence for fosfomycin is lacking and a meaningful effect is unlikely.
How serious is the interaction between Conjugated estrogens and Fosfomycin?
MediHelp rates it minor, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: No routine change is needed. Ask the patient to report breakthrough bleeding or symptom recurrence.
What other medicines interact with Fosfomycin?
MediHelp also lists interactions of Fosfomycin with, for example, Cholera vaccine, Metoclopramide, Metoclopramide intranasal. The full list is on the Fosfomycin page.
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