Drug interactions
Corticotropin + Gemifloxacin
Severity: Moderate
Corticotropin and Gemifloxacin: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Fluoroquinolones carry a risk of tendinitis and tendon rupture, and corticosteroid exposure, including that driven by corticotropin, adds to it. Risk is highest in older adults and those on prolonged or high-dose therapy.
What this interaction means in plain words
Corticotropin and Gemifloxacin can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Corticotropin belongs to Endocrine; Gemifloxacin belongs to Anti Bacterial.
Why it happens
Additive tendon toxicity, as corticotropin raises endogenous cortisol, which impairs collagen synthesis, alongside fluoroquinolone-related tenocyte damage.
What to do
Avoid the combination in patients over 60 or with tendon disease where an alternative antibiotic exists. Advise stopping gemifloxacin and resting if tendon pain develops.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Gemifloxacin
- Arsenic trioxide + Gemifloxacin Contraindicated
- Dofetilide + Gemifloxacin Contraindicated
- Gemifloxacin + Ibutilide Contraindicated
- Gemifloxacin + Pimozide Contraindicated
- Gemifloxacin + Thioridazine Contraindicated
- Gemifloxacin + Vandetanib Contraindicated
Other interactions of Corticotropin
Frequently asked questions
Can I take Corticotropin with Gemifloxacin?
MediHelp rates the interaction as moderate. Corticotropin and Gemifloxacin can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Fluoroquinolones carry a risk of tendinitis and tendon rupture, and corticosteroid exposure, including that driven by corticotropin, adds to it. Risk is highest in older adults and those on prolonged or high-dose therapy.
How serious is the interaction between Corticotropin and Gemifloxacin?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Avoid the combination in patients over 60 or with tendon disease where an alternative antibiotic exists. Advise stopping gemifloxacin and resting if tendon pain develops.
What other medicines interact with Gemifloxacin?
MediHelp also lists interactions of Gemifloxacin with, for example, Arsenic trioxide, Dofetilide, Ibutilide. The full list is on the Gemifloxacin page.
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