Drug interactions
Corticotropin + Moxifloxacin
Severity: Moderate
Corticotropin and Moxifloxacin: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Corticotropin stimulates endogenous corticosteroid release, and corticosteroid exposure increases the risk of fluoroquinolone-associated tendinopathy and tendon rupture. The risk is greater in older adults and with prolonged use.
What this interaction means in plain words
Corticotropin and Moxifloxacin can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Corticotropin belongs to Endocrine; Moxifloxacin belongs to Anti Bacterial.
Why it happens
Additive tendon toxicity from fluoroquinolone-induced tenocyte damage and corticosteroid-impaired collagen repair.
What to do
Prefer a non-fluoroquinolone antibiotic in older patients on corticotropin. Advise stopping moxifloxacin and resting if tendon pain develops.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Moxifloxacin
- Amiodarone + Moxifloxacin Contraindicated
- Arsenic trioxide + Moxifloxacin Contraindicated
- Disopyramide + Moxifloxacin Contraindicated
- Dofetilide + Moxifloxacin Contraindicated
- Dronedarone + Moxifloxacin Contraindicated
- Droperidol + Moxifloxacin Contraindicated
Other interactions of Corticotropin
Frequently asked questions
Can I take Corticotropin with Moxifloxacin?
MediHelp rates the interaction as moderate. Corticotropin and Moxifloxacin can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Corticotropin stimulates endogenous corticosteroid release, and corticosteroid exposure increases the risk of fluoroquinolone-associated tendinopathy and tendon rupture. The risk is greater in older adults and with prolonged use.
How serious is the interaction between Corticotropin and Moxifloxacin?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Prefer a non-fluoroquinolone antibiotic in older patients on corticotropin. Advise stopping moxifloxacin and resting if tendon pain develops.
What other medicines interact with Moxifloxacin?
MediHelp also lists interactions of Moxifloxacin with, for example, Amiodarone, Arsenic trioxide, Disopyramide. The full list is on the Moxifloxacin page.
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