Drug interactions
Corticotropin + Succinylcholine
Severity: Minor
Corticotropin and Succinylcholine: minor interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Corticotropin stimulates endogenous corticosteroid release, and corticosteroids given with neuromuscular blockers have been linked to acute myopathy in critically ill patients. This is mostly reported with prolonged use of nondepolarizing agents. Corticotropin may also cause hypokalemia, which can affect neuromuscular function.
What this interaction means in plain words
Corticotropin and Succinylcholine have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised.
Corticotropin belongs to Endocrine; Succinylcholine belongs to Musculoskeletal.
Why it happens
Corticosteroid-associated myopathy and potassium shifts may add to neuromuscular blockade; the mechanism is not fully established.
What to do
Monitor neuromuscular recovery and serum potassium in patients receiving corticotropin. Limit the duration of neuromuscular blockade in critically ill patients.
What to ask your pharmacist
- Is there anything I should notice while taking both?
- Do I need to tell my doctor at the next visit?
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Other interactions of Succinylcholine
Other interactions of Corticotropin
Frequently asked questions
Can I take Corticotropin with Succinylcholine?
MediHelp rates the interaction as minor. Corticotropin and Succinylcholine have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised. Corticotropin stimulates endogenous corticosteroid release, and corticosteroids given with neuromuscular blockers have been linked to acute myopathy in critically ill patients. This is mostly reported with prolonged use of nondepolarizing agents. Corticotropin may also cause hypokalemia, which can affect neuromuscular function.
How serious is the interaction between Corticotropin and Succinylcholine?
MediHelp rates it minor, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor neuromuscular recovery and serum potassium in patients receiving corticotropin. Limit the duration of neuromuscular blockade in critically ill patients.
What other medicines interact with Succinylcholine?
MediHelp also lists interactions of Succinylcholine with, for example, Amikacin, Bacitracin-neomycin-polymyxin, Capreomycin. The full list is on the Succinylcholine page.
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