Drug interactions
Crizotinib + Dapsone
Severity: Moderate
Crizotinib and Dapsone: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Crizotinib is a moderate CYP3A inhibitor and may raise dapsone concentrations. Higher exposure could worsen haemolysis and methaemoglobinaemia.
What this interaction means in plain words
Crizotinib and Dapsone can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Crizotinib belongs to Oncology; Dapsone belongs to Anti Bacterial.
Why it happens
Inhibition of CYP3A4 by crizotinib reduces dapsone clearance.
What to do
Monitor full blood count and methaemoglobin levels, and watch for dapsone toxicity such as cyanosis or dyspnoea.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Dapsone
- Bcg vaccine live + Dapsone Major
- Dapsone + Primaquine Major
- Apalutamide + Dapsone Moderate
- Belzutifan + Dapsone Moderate
- Bosentan + Dapsone Moderate
- Bupivacaine implant + Dapsone Moderate
Other interactions of Crizotinib
- Crizotinib + Flibanserin Contraindicated
- Crizotinib + Lomitapide Contraindicated
- Crizotinib + Lonafarnib Contraindicated
- Crizotinib + Pimozide Contraindicated
- Crizotinib + Saquinavir Contraindicated
- Crizotinib + Thioridazine Contraindicated
Frequently asked questions
Can I take Crizotinib with Dapsone?
MediHelp rates the interaction as moderate. Crizotinib and Dapsone can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Crizotinib is a moderate CYP3A inhibitor and may raise dapsone concentrations. Higher exposure could worsen haemolysis and methaemoglobinaemia.
How serious is the interaction between Crizotinib and Dapsone?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor full blood count and methaemoglobin levels, and watch for dapsone toxicity such as cyanosis or dyspnoea.
What other medicines interact with Dapsone?
MediHelp also lists interactions of Dapsone with, for example, Bcg vaccine live, Primaquine, Apalutamide. The full list is on the Dapsone page.
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