Drug interactions
Crizotinib + Daridorexant
Severity: Moderate
Crizotinib and Daridorexant: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Crizotinib may increase daridorexant exposure, which may cause excess next-day somnolence and impaired driving.
What this interaction means in plain words
Crizotinib and Daridorexant can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Crizotinib belongs to Oncology; Daridorexant belongs to Central Nervous System.
Why it happens
Crizotinib inhibits CYP3A4, reducing daridorexant clearance.
What to do
Limit daridorexant to 25 mg nightly with a moderate CYP3A4 inhibitor. Counsel on next-day drowsiness.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
Pro+ members
Unlock the full page
Create an account and start a Pro+ trial to unlock the full management advice for Crizotinib and Daridorexant, the additional notes, the evidence detail and the whole-prescription interaction checker.
- Full clinical management advice
- Additional notes
- Evidence detail
- Interaction checker for a whole prescription
Try Pro+ free for 7 days on the web. No card needed.
Other interactions of Crizotinib
- Crizotinib + Flibanserin Contraindicated
- Crizotinib + Lomitapide Contraindicated
- Crizotinib + Lonafarnib Contraindicated
- Crizotinib + Pimozide Contraindicated
- Crizotinib + Saquinavir Contraindicated
- Crizotinib + Thioridazine Contraindicated
Other interactions of Daridorexant
Frequently asked questions
Can I take Crizotinib with Daridorexant?
MediHelp rates the interaction as moderate. Crizotinib and Daridorexant can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Crizotinib may increase daridorexant exposure, which may cause excess next-day somnolence and impaired driving.
How serious is the interaction between Crizotinib and Daridorexant?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Limit daridorexant to 25 mg nightly with a moderate CYP3A4 inhibitor. Counsel on next-day drowsiness.
What other medicines interact with Crizotinib?
MediHelp also lists interactions of Crizotinib with, for example, Flibanserin, Lomitapide, Lonafarnib. The full list is on the Crizotinib page.
Full monographs, dosing and an interaction checker in the MediHelp app
Open the complete reference, check multi-drug interactions and use dosing tools in the MediHelp app.
