Drug interactions
Crizotinib + Darunavir
Severity: Major
Crizotinib and Darunavir: major interaction.
Last updated Sources: US FDA label
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Darunavir, usually given with a booster such as ritonavir or cobicistat, is a strong CYP3A inhibitor and can markedly raise crizotinib levels. Crizotinib may also raise darunavir levels through CYP3A inhibition. Increased crizotinib exposure raises the risk of hepatotoxicity, QT prolongation and bradycardia.
What this interaction means in plain words
Crizotinib and Darunavir can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for.
Crizotinib belongs to Oncology; Darunavir belongs to Anti Virals.
Why it happens
Inhibition of CYP3A4 by boosted darunavir reduces crizotinib clearance, and crizotinib inhibits CYP3A4 in turn.
What to do
Avoid the combination where possible. If it cannot be avoided, reduce the crizotinib dose per labeling and monitor ECG and liver function.
What to ask your pharmacist
- Does the benefit of taking both outweigh the risk in my case?
- Do I need any blood test, ECG or other check while on both?
- What early warning signs should I watch for, and what should I do if they appear?
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References
Other interactions of Crizotinib
- Crizotinib + Flibanserin Contraindicated
- Crizotinib + Lomitapide Contraindicated
- Crizotinib + Lonafarnib Contraindicated
- Crizotinib + Pimozide Contraindicated
- Crizotinib + Saquinavir Contraindicated
- Crizotinib + Thioridazine Contraindicated
Other interactions of Darunavir
- Alfuzosin + Darunavir Contraindicated
- Avanafil + Darunavir Contraindicated
- Darunavir + Dronedarone Contraindicated
- Darunavir + Eletriptan Contraindicated
- Darunavir + Ergotamine Contraindicated
- Darunavir + Flibanserin Contraindicated
Frequently asked questions
Can I take Crizotinib with Darunavir?
MediHelp rates the interaction as major. Crizotinib and Darunavir can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for. Darunavir, usually given with a booster such as ritonavir or cobicistat, is a strong CYP3A inhibitor and can markedly raise crizotinib levels. Crizotinib may also raise darunavir levels through CYP3A inhibition. Increased crizotinib exposure raises the risk of hepatotoxicity, QT prolongation and bradycardia.
How serious is the interaction between Crizotinib and Darunavir?
MediHelp rates it major, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Avoid the combination where possible. If it cannot be avoided, reduce the crizotinib dose per labeling and monitor ECG and liver function.
What other medicines interact with Crizotinib?
MediHelp also lists interactions of Crizotinib with, for example, Flibanserin, Lomitapide, Lonafarnib. The full list is on the Crizotinib page.
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