Drug interactions
Crizotinib + Dasatinib
Severity: Major
Crizotinib and Dasatinib: major interaction.
Last updated Sources: UK SmPC
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Both kinase inhibitors can prolong the QT interval, so concurrent use increases the likelihood of serious ventricular arrhythmia. Crizotinib can also cause bradycardia, which adds to the risk.
What this interaction means in plain words
Crizotinib and Dasatinib can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for.
Crizotinib belongs to Oncology; Dasatinib belongs to Oncology.
Why it happens
Additive QT prolongation.
What to do
Avoid the combination if feasible. If both are required, monitor ECG and electrolytes regularly and reduce or stop one drug if QTc becomes markedly prolonged.
What to ask your pharmacist
- Does the benefit of taking both outweigh the risk in my case?
- Do I need any blood test, ECG or other check while on both?
- What early warning signs should I watch for, and what should I do if they appear?
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References
Other interactions of Dasatinib
- Dasatinib + Saquinavir Contraindicated
- Dasatinib + Thioridazine Contraindicated
- Adagrasib + Dasatinib Major
- Amiodarone + Dasatinib Major
- Amisulpride + Dasatinib Major
- Amitriptyline + Dasatinib Major
Other interactions of Crizotinib
- Crizotinib + Flibanserin Contraindicated
- Crizotinib + Lomitapide Contraindicated
- Crizotinib + Lonafarnib Contraindicated
- Crizotinib + Pimozide Contraindicated
- Crizotinib + Saquinavir Contraindicated
- Crizotinib + Thioridazine Contraindicated
Frequently asked questions
Can I take Crizotinib with Dasatinib?
MediHelp rates the interaction as major. Crizotinib and Dasatinib can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for. Both kinase inhibitors can prolong the QT interval, so concurrent use increases the likelihood of serious ventricular arrhythmia. Crizotinib can also cause bradycardia, which adds to the risk.
How serious is the interaction between Crizotinib and Dasatinib?
MediHelp rates it major, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Avoid the combination if feasible. If both are required, monitor ECG and electrolytes regularly and reduce or stop one drug if QTc becomes markedly prolonged.
What other medicines interact with Dasatinib?
MediHelp also lists interactions of Dasatinib with, for example, Saquinavir, Thioridazine, Adagrasib. The full list is on the Dasatinib page.
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