Drug interactions
Crizotinib + Desflurane
Severity: Major
Crizotinib and Desflurane: major interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Crizotinib prolongs the QT interval and also causes bradycardia, and desflurane may add to the QT effect. The combination may raise the risk of torsades de pointes.
What this interaction means in plain words
Crizotinib and Desflurane can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for.
Crizotinib belongs to Oncology; Desflurane belongs to Central Nervous System.
Why it happens
Additive pharmacodynamic QT prolongation, with crizotinib-related bradycardia.
What to do
Check ECG, heart rate and electrolytes before surgery and correct abnormalities. Monitor the ECG during anesthesia and have bradycardia treatment available.
What to ask your pharmacist
- Does the benefit of taking both outweigh the risk in my case?
- Do I need any blood test, ECG or other check while on both?
- What early warning signs should I watch for, and what should I do if they appear?
Pro+ members
Unlock the full page
Create an account and start a Pro+ trial to unlock the full management advice for Crizotinib and Desflurane, the additional notes, the evidence detail and the whole-prescription interaction checker.
- Full clinical management advice
- Additional notes
- Evidence detail
- Interaction checker for a whole prescription
Try Pro+ free for 7 days on the web. No card needed.
Other interactions of Desflurane
Other interactions of Crizotinib
- Crizotinib + Flibanserin Contraindicated
- Crizotinib + Lomitapide Contraindicated
- Crizotinib + Lonafarnib Contraindicated
- Crizotinib + Pimozide Contraindicated
- Crizotinib + Saquinavir Contraindicated
- Crizotinib + Thioridazine Contraindicated
Frequently asked questions
Can I take Crizotinib with Desflurane?
MediHelp rates the interaction as major. Crizotinib and Desflurane can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for. Crizotinib prolongs the QT interval and also causes bradycardia, and desflurane may add to the QT effect. The combination may raise the risk of torsades de pointes.
How serious is the interaction between Crizotinib and Desflurane?
MediHelp rates it major, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Check ECG, heart rate and electrolytes before surgery and correct abnormalities. Monitor the ECG during anesthesia and have bradycardia treatment available.
What other medicines interact with Desflurane?
MediHelp also lists interactions of Desflurane with, for example, Amisulpride, Anagrelide, Arsenic trioxide. The full list is on the Desflurane page.
Full monographs, dosing and an interaction checker in the MediHelp app
Open the complete reference, check multi-drug interactions and use dosing tools in the MediHelp app.
