Drug interactions
Crizotinib + Edoxaban
Severity: Moderate
Crizotinib and Edoxaban: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Crizotinib inhibits P-glycoprotein and may raise edoxaban concentrations, increasing bleeding risk. Crizotinib itself can cause hematologic effects.
What this interaction means in plain words
Crizotinib and Edoxaban can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Crizotinib belongs to Oncology; Edoxaban belongs to Cardiovascular.
Why it happens
Inhibition of P-glycoprotein efflux increases edoxaban exposure.
What to do
Monitor for bleeding and blood counts; consider edoxaban dose reduction in patients with other risk factors such as renal impairment.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Edoxaban
- Apixaban + Edoxaban Contraindicated
- Defibrotide + Edoxaban Contraindicated
- Edoxaban + Ketorolac Contraindicated
- Abciximab + Edoxaban Major
- Acetylsalicylic acid + Edoxaban Major
- Argatroban + Edoxaban Major
Other interactions of Crizotinib
- Crizotinib + Flibanserin Contraindicated
- Crizotinib + Lomitapide Contraindicated
- Crizotinib + Lonafarnib Contraindicated
- Crizotinib + Pimozide Contraindicated
- Crizotinib + Saquinavir Contraindicated
- Crizotinib + Thioridazine Contraindicated
Frequently asked questions
Can I take Crizotinib with Edoxaban?
MediHelp rates the interaction as moderate. Crizotinib and Edoxaban can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Crizotinib inhibits P-glycoprotein and may raise edoxaban concentrations, increasing bleeding risk. Crizotinib itself can cause hematologic effects.
How serious is the interaction between Crizotinib and Edoxaban?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor for bleeding and blood counts; consider edoxaban dose reduction in patients with other risk factors such as renal impairment.
What other medicines interact with Edoxaban?
MediHelp also lists interactions of Edoxaban with, for example, Apixaban, Defibrotide, Ketorolac. The full list is on the Edoxaban page.
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