Drug interactions
Crizotinib + Eliglustat
Severity: Major
Crizotinib and Eliglustat: major interaction.
Last updated Sources: US FDA label
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Crizotinib may increase eliglustat concentrations by inhibiting CYP3A4, and both agents can prolong the QT interval. Elevated eliglustat levels raise the risk of cardiac conduction abnormalities and arrhythmia.
What this interaction means in plain words
Crizotinib and Eliglustat can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for.
Crizotinib belongs to Oncology; Eliglustat belongs to Miscellaneous.
Why it happens
Crizotinib inhibits CYP3A4 (eliglustat metabolism) and both drugs have additive QTc-prolonging effects.
What to do
Avoid the combination in CYP2D6 poor or intermediate metabolizers; in extensive metabolizers reduce eliglustat dose per labeling and monitor ECG.
What to ask your pharmacist
- Does the benefit of taking both outweigh the risk in my case?
- Do I need any blood test, ECG or other check while on both?
- What early warning signs should I watch for, and what should I do if they appear?
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References
Other interactions of Crizotinib
- Crizotinib + Flibanserin Contraindicated
- Crizotinib + Lomitapide Contraindicated
- Crizotinib + Lonafarnib Contraindicated
- Crizotinib + Pimozide Contraindicated
- Crizotinib + Saquinavir Contraindicated
- Crizotinib + Thioridazine Contraindicated
Other interactions of Eliglustat
- Amiodarone + Eliglustat Contraindicated
- Clarithromycin + Eliglustat Contraindicated
- Dronedarone + Eliglustat Contraindicated
- Eliglustat + Itraconazole Contraindicated
- Eliglustat + Ketoconazole Contraindicated
- Eliglustat + Pimozide Contraindicated
Frequently asked questions
Can I take Crizotinib with Eliglustat?
MediHelp rates the interaction as major. Crizotinib and Eliglustat can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for. Crizotinib may increase eliglustat concentrations by inhibiting CYP3A4, and both agents can prolong the QT interval. Elevated eliglustat levels raise the risk of cardiac conduction abnormalities and arrhythmia.
How serious is the interaction between Crizotinib and Eliglustat?
MediHelp rates it major, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Avoid the combination in CYP2D6 poor or intermediate metabolizers; in extensive metabolizers reduce eliglustat dose per labeling and monitor ECG.
What other medicines interact with Crizotinib?
MediHelp also lists interactions of Crizotinib with, for example, Flibanserin, Lomitapide, Lonafarnib. The full list is on the Crizotinib page.
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