Drug interactions
Crizotinib + Fosaprepitant
Severity: Moderate
Crizotinib and Fosaprepitant: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Fosaprepitant is converted to aprepitant, a moderate CYP3A4 inhibitor, which may raise crizotinib exposure for a few days. The effect is likely modest with single-dose use.
What this interaction means in plain words
Crizotinib and Fosaprepitant can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Crizotinib belongs to Oncology; Fosaprepitant belongs to Gastrointestinal Tract.
Why it happens
Aprepitant inhibits CYP3A4, reducing crizotinib clearance.
What to do
Monitor for crizotinib adverse effects such as bradycardia, QT prolongation and hepatotoxicity around chemotherapy cycles. No empiric dose change is usually needed.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Crizotinib
- Crizotinib + Flibanserin Contraindicated
- Crizotinib + Lomitapide Contraindicated
- Crizotinib + Lonafarnib Contraindicated
- Crizotinib + Pimozide Contraindicated
- Crizotinib + Saquinavir Contraindicated
- Crizotinib + Thioridazine Contraindicated
Other interactions of Fosaprepitant
- Flibanserin + Fosaprepitant Contraindicated
- Fosaprepitant + Pimozide Contraindicated
- Alprazolam + Fosaprepitant Moderate
- Amiodarone + Fosaprepitant Moderate
- Amobarbital + Fosaprepitant Moderate
- Apalutamide + Fosaprepitant Moderate
Frequently asked questions
Can I take Crizotinib with Fosaprepitant?
MediHelp rates the interaction as moderate. Crizotinib and Fosaprepitant can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Fosaprepitant is converted to aprepitant, a moderate CYP3A4 inhibitor, which may raise crizotinib exposure for a few days. The effect is likely modest with single-dose use.
How serious is the interaction between Crizotinib and Fosaprepitant?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor for crizotinib adverse effects such as bradycardia, QT prolongation and hepatotoxicity around chemotherapy cycles. No empiric dose change is usually needed.
What other medicines interact with Crizotinib?
MediHelp also lists interactions of Crizotinib with, for example, Flibanserin, Lomitapide, Lonafarnib. The full list is on the Crizotinib page.
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