Drug interactions
Crizotinib + Lasmiditan
Severity: Moderate
Crizotinib and Lasmiditan: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Lasmiditan inhibits intestinal P-glycoprotein, which may raise systemic exposure to P-gp substrates such as crizotinib. Higher crizotinib levels could increase dose-related adverse effects such as QT prolongation, hepatotoxicity, bradycardia and visual disturbance.
What this interaction means in plain words
Crizotinib and Lasmiditan can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Crizotinib belongs to Oncology; Lasmiditan belongs to Central Nervous System.
Why it happens
Lasmiditan inhibits P-glycoprotein efflux, increasing absorption and exposure of crizotinib.
What to do
Prefer an alternative acute migraine therapy where practical. If both are used, monitor for crizotinib toxicity including heart rate, ECG and liver enzymes.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Crizotinib
- Crizotinib + Flibanserin Contraindicated
- Crizotinib + Lomitapide Contraindicated
- Crizotinib + Lonafarnib Contraindicated
- Crizotinib + Pimozide Contraindicated
- Crizotinib + Saquinavir Contraindicated
- Crizotinib + Thioridazine Contraindicated
Other interactions of Lasmiditan
- Alprazolam + Lasmiditan Moderate
- Amiodarone + Lasmiditan Moderate
- Amisulpride + Lasmiditan Moderate
- Amobarbital + Lasmiditan Moderate
- Aripiprazole + Lasmiditan Moderate
- Asenapine + Lasmiditan Moderate
Frequently asked questions
Can I take Crizotinib with Lasmiditan?
MediHelp rates the interaction as moderate. Crizotinib and Lasmiditan can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Lasmiditan inhibits intestinal P-glycoprotein, which may raise systemic exposure to P-gp substrates such as crizotinib. Higher crizotinib levels could increase dose-related adverse effects such as QT prolongation, hepatotoxicity, bradycardia and visual disturbance.
How serious is the interaction between Crizotinib and Lasmiditan?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Prefer an alternative acute migraine therapy where practical. If both are used, monitor for crizotinib toxicity including heart rate, ECG and liver enzymes.
What other medicines interact with Crizotinib?
MediHelp also lists interactions of Crizotinib with, for example, Flibanserin, Lomitapide, Lonafarnib. The full list is on the Crizotinib page.
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