Drug interactions
Crizotinib + Liposomal doxorubicin
Severity: Moderate
Crizotinib and Liposomal doxorubicin: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Crizotinib inhibits CYP3A4 and P-glycoprotein and may modestly raise doxorubicin exposure. Higher exposure could increase myelosuppression and cardiotoxicity. Crizotinib can also cause bradycardia and QT prolongation.
What this interaction means in plain words
Crizotinib and Liposomal doxorubicin can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Crizotinib belongs to Oncology; Liposomal doxorubicin belongs to Oncology.
Why it happens
Crizotinib inhibits CYP3A4 and P-glycoprotein, reducing doxorubicin clearance.
What to do
Monitor blood counts, heart rate, ECG and cardiac function. Reduce the doxorubicin dose if toxicity develops.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Liposomal doxorubicin
- Dengue vaccine + Liposomal doxorubicin Contraindicated
- Belatacept + Liposomal doxorubicin Major
- Cyclosporine + Liposomal doxorubicin Major
- Dronedarone + Liposomal doxorubicin Major
- Elvitegravir / cobicistat / emtricitabine / tenofovir df + Liposomal doxorubicin Major
- Fingolimod + Liposomal doxorubicin Major
Other interactions of Crizotinib
- Crizotinib + Flibanserin Contraindicated
- Crizotinib + Lomitapide Contraindicated
- Crizotinib + Lonafarnib Contraindicated
- Crizotinib + Pimozide Contraindicated
- Crizotinib + Saquinavir Contraindicated
- Crizotinib + Thioridazine Contraindicated
Frequently asked questions
Can I take Crizotinib with Liposomal doxorubicin?
MediHelp rates the interaction as moderate. Crizotinib and Liposomal doxorubicin can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Crizotinib inhibits CYP3A4 and P-glycoprotein and may modestly raise doxorubicin exposure. Higher exposure could increase myelosuppression and cardiotoxicity. Crizotinib can also cause bradycardia and QT prolongation.
How serious is the interaction between Crizotinib and Liposomal doxorubicin?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor blood counts, heart rate, ECG and cardiac function. Reduce the doxorubicin dose if toxicity develops.
What other medicines interact with Liposomal doxorubicin?
MediHelp also lists interactions of Liposomal doxorubicin with, for example, Dengue vaccine, Belatacept, Cyclosporine. The full list is on the Liposomal doxorubicin page.
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