Drug interactions
Crizotinib + Macimorelin
Severity: Major
Crizotinib and Macimorelin: major interaction.
Last updated Sources: US FDA label
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Both agents can prolong the QTc interval, and combined use may raise the risk of torsade de pointes. Macimorelin is given as a single diagnostic dose, but crizotinib's long-lasting effect can persist.
What this interaction means in plain words
Crizotinib and Macimorelin can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for.
Crizotinib belongs to Oncology; Macimorelin belongs to Endocrine.
Why it happens
Additive pharmacodynamic QT prolongation.
What to do
Avoid macimorelin testing while the patient takes crizotinib; use an alternative growth hormone stimulation test if possible. If testing is essential, check ECG and electrolytes beforehand.
What to ask your pharmacist
- Does the benefit of taking both outweigh the risk in my case?
- Do I need any blood test, ECG or other check while on both?
- What early warning signs should I watch for, and what should I do if they appear?
Pro+ members
Unlock the full page
Create an account and start a Pro+ trial to unlock the full management advice for Crizotinib and Macimorelin, the additional notes, the evidence detail and the whole-prescription interaction checker.
- Full clinical management advice
- Additional notes
- Evidence detail
- Interaction checker for a whole prescription
Try Pro+ free for 7 days on the web. No card needed.
References
Other interactions of Crizotinib
- Crizotinib + Flibanserin Contraindicated
- Crizotinib + Lomitapide Contraindicated
- Crizotinib + Lonafarnib Contraindicated
- Crizotinib + Pimozide Contraindicated
- Crizotinib + Saquinavir Contraindicated
- Crizotinib + Thioridazine Contraindicated
Other interactions of Macimorelin
Frequently asked questions
Can I take Crizotinib with Macimorelin?
MediHelp rates the interaction as major. Crizotinib and Macimorelin can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for. Both agents can prolong the QTc interval, and combined use may raise the risk of torsade de pointes. Macimorelin is given as a single diagnostic dose, but crizotinib's long-lasting effect can persist.
How serious is the interaction between Crizotinib and Macimorelin?
MediHelp rates it major, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Avoid macimorelin testing while the patient takes crizotinib; use an alternative growth hormone stimulation test if possible. If testing is essential, check ECG and electrolytes beforehand.
What other medicines interact with Crizotinib?
MediHelp also lists interactions of Crizotinib with, for example, Flibanserin, Lomitapide, Lonafarnib. The full list is on the Crizotinib page.
Full monographs, dosing and an interaction checker in the MediHelp app
Open the complete reference, check multi-drug interactions and use dosing tools in the MediHelp app.
