Drug interactions
Crizotinib + Osimertinib
Severity: Moderate
Crizotinib and Osimertinib: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Both agents can prolong the QTc interval, so combined use may increase the risk of serious ventricular arrhythmia. Patients with electrolyte disturbances or heart disease are at greatest risk.
What this interaction means in plain words
Crizotinib and Osimertinib can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Crizotinib belongs to Oncology; Osimertinib belongs to Oncology.
Why it happens
Additive pharmacodynamic QT interval prolongation.
What to do
Monitor ECG and electrolytes periodically and correct hypokalemia or hypomagnesemia; interrupt therapy if QTc becomes markedly prolonged.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Crizotinib
- Crizotinib + Flibanserin Contraindicated
- Crizotinib + Lomitapide Contraindicated
- Crizotinib + Lonafarnib Contraindicated
- Crizotinib + Pimozide Contraindicated
- Crizotinib + Saquinavir Contraindicated
- Crizotinib + Thioridazine Contraindicated
Other interactions of Osimertinib
Frequently asked questions
Can I take Crizotinib with Osimertinib?
MediHelp rates the interaction as moderate. Crizotinib and Osimertinib can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Both agents can prolong the QTc interval, so combined use may increase the risk of serious ventricular arrhythmia. Patients with electrolyte disturbances or heart disease are at greatest risk.
How serious is the interaction between Crizotinib and Osimertinib?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor ECG and electrolytes periodically and correct hypokalemia or hypomagnesemia; interrupt therapy if QTc becomes markedly prolonged.
What other medicines interact with Crizotinib?
MediHelp also lists interactions of Crizotinib with, for example, Flibanserin, Lomitapide, Lonafarnib. The full list is on the Crizotinib page.
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