Drug interactions
Crizotinib + Rilpivirine
Severity: Moderate
Crizotinib and Rilpivirine: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Crizotinib inhibits CYP3A4 and may increase rilpivirine concentrations. Both drugs can prolong the QT interval, so higher rilpivirine exposure adds to arrhythmia risk.
What this interaction means in plain words
Crizotinib and Rilpivirine can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Crizotinib belongs to Oncology; Rilpivirine belongs to Anti Virals.
Why it happens
Crizotinib inhibits CYP3A4 metabolism of rilpivirine, with possible additive QT effects.
What to do
Monitor ECG and electrolytes, and watch for rilpivirine adverse effects such as sleep disturbance and rash.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Crizotinib
- Crizotinib + Flibanserin Contraindicated
- Crizotinib + Lomitapide Contraindicated
- Crizotinib + Lonafarnib Contraindicated
- Crizotinib + Pimozide Contraindicated
- Crizotinib + Saquinavir Contraindicated
- Crizotinib + Thioridazine Contraindicated
Other interactions of Rilpivirine
- Carbamazepine + Rilpivirine Contraindicated
- Dexamethasone + Rilpivirine Contraindicated
- Dexlansoprazole + Rilpivirine Contraindicated
- Efavirenz + Rilpivirine Contraindicated
- Eslicarbazepine + Rilpivirine Contraindicated
- Esomeprazole + Rilpivirine Contraindicated
Frequently asked questions
Can I take Crizotinib with Rilpivirine?
MediHelp rates the interaction as moderate. Crizotinib and Rilpivirine can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Crizotinib inhibits CYP3A4 and may increase rilpivirine concentrations. Both drugs can prolong the QT interval, so higher rilpivirine exposure adds to arrhythmia risk.
How serious is the interaction between Crizotinib and Rilpivirine?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor ECG and electrolytes, and watch for rilpivirine adverse effects such as sleep disturbance and rash.
What other medicines interact with Crizotinib?
MediHelp also lists interactions of Crizotinib with, for example, Flibanserin, Lomitapide, Lonafarnib. The full list is on the Crizotinib page.
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