Drug interactions
Crizotinib + Rimegepant
Severity: Moderate
Crizotinib and Rimegepant: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Crizotinib, a moderate CYP3A4 inhibitor, increases rimegepant exposure. The increased exposure may heighten adverse effects such as nausea and hypersensitivity.
What this interaction means in plain words
Crizotinib and Rimegepant can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Crizotinib belongs to Oncology; Rimegepant belongs to Central Nervous System.
Why it happens
Crizotinib inhibits CYP3A4, decreasing rimegepant metabolism.
What to do
Avoid a second rimegepant dose within 48 hours while crizotinib is being taken, per labeling.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Crizotinib
- Crizotinib + Flibanserin Contraindicated
- Crizotinib + Lomitapide Contraindicated
- Crizotinib + Lonafarnib Contraindicated
- Crizotinib + Pimozide Contraindicated
- Crizotinib + Saquinavir Contraindicated
- Crizotinib + Thioridazine Contraindicated
Other interactions of Rimegepant
Frequently asked questions
Can I take Crizotinib with Rimegepant?
MediHelp rates the interaction as moderate. Crizotinib and Rimegepant can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Crizotinib, a moderate CYP3A4 inhibitor, increases rimegepant exposure. The increased exposure may heighten adverse effects such as nausea and hypersensitivity.
How serious is the interaction between Crizotinib and Rimegepant?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Avoid a second rimegepant dose within 48 hours while crizotinib is being taken, per labeling.
What other medicines interact with Crizotinib?
MediHelp also lists interactions of Crizotinib with, for example, Flibanserin, Lomitapide, Lonafarnib. The full list is on the Crizotinib page.
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