Drug interactions
Crizotinib + Saxagliptin
Severity: Moderate
Crizotinib and Saxagliptin: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Crizotinib is a moderate CYP3A4 inhibitor and P-gp inhibitor, so it may increase saxagliptin and its active metabolite exposure. This could modestly raise the risk of saxagliptin adverse effects.
What this interaction means in plain words
Crizotinib and Saxagliptin can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Crizotinib belongs to Oncology; Saxagliptin belongs to Endocrine.
Why it happens
Crizotinib inhibits CYP3A4 and P-glycoprotein, reducing saxagliptin clearance.
What to do
Monitor glycemic response and for adverse effects; the saxagliptin dose is not routinely changed, as the label limits the dose only with strong CYP3A4 inhibitors.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Saxagliptin
- Albiglutide + Saxagliptin Moderate
- Amlodipine-benazepril + Saxagliptin Moderate
- Aripiprazole + Saxagliptin Moderate
- Asenapine + Saxagliptin Moderate
- Atazanavir + Saxagliptin Moderate
- Benazepril + Saxagliptin Moderate
Other interactions of Crizotinib
- Crizotinib + Flibanserin Contraindicated
- Crizotinib + Lomitapide Contraindicated
- Crizotinib + Lonafarnib Contraindicated
- Crizotinib + Pimozide Contraindicated
- Crizotinib + Saquinavir Contraindicated
- Crizotinib + Thioridazine Contraindicated
Frequently asked questions
Can I take Crizotinib with Saxagliptin?
MediHelp rates the interaction as moderate. Crizotinib and Saxagliptin can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Crizotinib is a moderate CYP3A4 inhibitor and P-gp inhibitor, so it may increase saxagliptin and its active metabolite exposure. This could modestly raise the risk of saxagliptin adverse effects.
How serious is the interaction between Crizotinib and Saxagliptin?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor glycemic response and for adverse effects; the saxagliptin dose is not routinely changed, as the label limits the dose only with strong CYP3A4 inhibitors.
What other medicines interact with Saxagliptin?
MediHelp also lists interactions of Saxagliptin with, for example, Albiglutide, Amlodipine-benazepril, Aripiprazole. The full list is on the Saxagliptin page.
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