Drug interactions
Crizotinib + Tazemetostat
Severity: Moderate
Crizotinib and Tazemetostat: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Tazemetostat is a CYP3A substrate, and crizotinib may increase its exposure. This may increase dose-related adverse effects.
What this interaction means in plain words
Crizotinib and Tazemetostat can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Crizotinib belongs to Oncology; Tazemetostat belongs to Miscellaneous.
Why it happens
Crizotinib inhibits CYP3A4 metabolism of tazemetostat.
What to do
Avoid if possible. If unavoidable, reduce tazemetostat dose per labeling for moderate CYP3A inhibitors and monitor for toxicity.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Crizotinib
- Crizotinib + Flibanserin Contraindicated
- Crizotinib + Lomitapide Contraindicated
- Crizotinib + Lonafarnib Contraindicated
- Crizotinib + Pimozide Contraindicated
- Crizotinib + Saquinavir Contraindicated
- Crizotinib + Thioridazine Contraindicated
Other interactions of Tazemetostat
Frequently asked questions
Can I take Crizotinib with Tazemetostat?
MediHelp rates the interaction as moderate. Crizotinib and Tazemetostat can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Tazemetostat is a CYP3A substrate, and crizotinib may increase its exposure. This may increase dose-related adverse effects.
How serious is the interaction between Crizotinib and Tazemetostat?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Avoid if possible. If unavoidable, reduce tazemetostat dose per labeling for moderate CYP3A inhibitors and monitor for toxicity.
What other medicines interact with Crizotinib?
MediHelp also lists interactions of Crizotinib with, for example, Flibanserin, Lomitapide, Lonafarnib. The full list is on the Crizotinib page.
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