Drug interactions
Crizotinib + Vemurafenib
Severity: Major
Crizotinib and Vemurafenib: major interaction.
Last updated Sources: US FDA label
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Both drugs can prolong the QT interval, and combined use raises the risk of torsades de pointes. Vemurafenib is also a CYP3A4 inducer that may lower crizotinib exposure.
What this interaction means in plain words
Crizotinib and Vemurafenib can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for.
Crizotinib belongs to Oncology; Vemurafenib belongs to Oncology.
Why it happens
Additive QTc prolongation, with possible CYP3A4 induction by vemurafenib.
What to do
Avoid the combination if possible; otherwise monitor ECG and electrolytes regularly and correct abnormalities promptly.
What to ask your pharmacist
- Does the benefit of taking both outweigh the risk in my case?
- Do I need any blood test, ECG or other check while on both?
- What early warning signs should I watch for, and what should I do if they appear?
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References
Other interactions of Crizotinib
- Crizotinib + Flibanserin Contraindicated
- Crizotinib + Lomitapide Contraindicated
- Crizotinib + Lonafarnib Contraindicated
- Crizotinib + Pimozide Contraindicated
- Crizotinib + Saquinavir Contraindicated
- Crizotinib + Thioridazine Contraindicated
Other interactions of Vemurafenib
Frequently asked questions
Can I take Crizotinib with Vemurafenib?
MediHelp rates the interaction as major. Crizotinib and Vemurafenib can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for. Both drugs can prolong the QT interval, and combined use raises the risk of torsades de pointes. Vemurafenib is also a CYP3A4 inducer that may lower crizotinib exposure.
How serious is the interaction between Crizotinib and Vemurafenib?
MediHelp rates it major, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Avoid the combination if possible; otherwise monitor ECG and electrolytes regularly and correct abnormalities promptly.
What other medicines interact with Crizotinib?
MediHelp also lists interactions of Crizotinib with, for example, Flibanserin, Lomitapide, Lonafarnib. The full list is on the Crizotinib page.
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