Drug interactions
Crofelemer + Dutasteride-tamsulosin
Severity: Minor
Crofelemer and Dutasteride-tamsulosin: minor interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Crofelemer is minimally absorbed and may inhibit CYP3A4 only in the gut lumen. A meaningful rise in tamsulosin or dutasteride exposure is unlikely.
What this interaction means in plain words
Crofelemer and Dutasteride-tamsulosin have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised.
Crofelemer belongs to Gastrointestinal Tract; Dutasteride-tamsulosin belongs to Genitourinary.
Why it happens
Possible local intestinal CYP3A4 inhibition.
What to do
No adjustment is generally needed. Watch for dizziness or hypotension if symptoms appear.
What to ask your pharmacist
- Is there anything I should notice while taking both?
- Do I need to tell my doctor at the next visit?
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Other interactions of Dutasteride-tamsulosin
Other interactions of Crofelemer
- Crofelemer + Ergotamine Moderate
- Alfuzosin + Crofelemer Minor
- Amiodarone + Crofelemer Minor
- Apixaban + Crofelemer Minor
- Aprepitant + Crofelemer Minor
- Armodafinil + Crofelemer Minor
Frequently asked questions
Can I take Crofelemer with Dutasteride-tamsulosin?
MediHelp rates the interaction as minor. Crofelemer and Dutasteride-tamsulosin have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised. Crofelemer is minimally absorbed and may inhibit CYP3A4 only in the gut lumen. A meaningful rise in tamsulosin or dutasteride exposure is unlikely.
How serious is the interaction between Crofelemer and Dutasteride-tamsulosin?
MediHelp rates it minor, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: No adjustment is generally needed. Watch for dizziness or hypotension if symptoms appear.
What other medicines interact with Dutasteride-tamsulosin?
MediHelp also lists interactions of Dutasteride-tamsulosin with, for example, Alfuzosin, Amifostine, Atazanavir. The full list is on the Dutasteride-tamsulosin page.
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