Drug interactions
Crofelemer + Hydrochlorothiazide-losartan
Severity: Minor
Crofelemer and Hydrochlorothiazide-losartan: minor interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Crofelemer is minimally absorbed and only inhibits CYP3A4 locally in the gut. Any change in losartan exposure is unlikely to be clinically meaningful.
What this interaction means in plain words
Crofelemer and Hydrochlorothiazide-losartan have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised.
Crofelemer belongs to Gastrointestinal Tract; Hydrochlorothiazide-losartan belongs to Cardiovascular.
Why it happens
Possible intestinal CYP3A4 inhibition with negligible systemic exposure to crofelemer.
What to do
No routine action is needed; monitor blood pressure if the patient's response changes.
What to ask your pharmacist
- Is there anything I should notice while taking both?
- Do I need to tell my doctor at the next visit?
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Other interactions of Hydrochlorothiazide-losartan
- Aliskiren + Hydrochlorothiazide-losartan Contraindicated
- Dofetilide + Hydrochlorothiazide-losartan Contraindicated
- Hydrochlorothiazide-losartan + Sparsentan Contraindicated
- Aceclofenac + Hydrochlorothiazide-losartan Major
- Aldesleukin + Hydrochlorothiazide-losartan Major
- Amifostine + Hydrochlorothiazide-losartan Major
Other interactions of Crofelemer
- Crofelemer + Ergotamine Moderate
- Alfuzosin + Crofelemer Minor
- Amiodarone + Crofelemer Minor
- Apixaban + Crofelemer Minor
- Aprepitant + Crofelemer Minor
- Armodafinil + Crofelemer Minor
Frequently asked questions
Can I take Crofelemer with Hydrochlorothiazide-losartan?
MediHelp rates the interaction as minor. Crofelemer and Hydrochlorothiazide-losartan have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised. Crofelemer is minimally absorbed and only inhibits CYP3A4 locally in the gut. Any change in losartan exposure is unlikely to be clinically meaningful.
How serious is the interaction between Crofelemer and Hydrochlorothiazide-losartan?
MediHelp rates it minor, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: No routine action is needed; monitor blood pressure if the patient's response changes.
What other medicines interact with Hydrochlorothiazide-losartan?
MediHelp also lists interactions of Hydrochlorothiazide-losartan with, for example, Aliskiren, Dofetilide, Sparsentan. The full list is on the Hydrochlorothiazide-losartan page.
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