Drug interactions
Crofelemer + Imatinib
Severity: Minor
Crofelemer and Imatinib: minor interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Crofelemer is minimally absorbed, so systemic interaction with imatinib is unlikely. It may inhibit CYP3A4 and transporters in the gut, but a meaningful change in imatinib exposure has not been demonstrated.
What this interaction means in plain words
Crofelemer and Imatinib have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised.
Crofelemer belongs to Gastrointestinal Tract; Imatinib belongs to Oncology.
Why it happens
Possible local intestinal inhibition of CYP3A4 and transporters; systemic effect is unlikely.
What to do
No routine action is needed; monitor for imatinib adverse effects if diarrhea management changes.
What to ask your pharmacist
- Is there anything I should notice while taking both?
- Do I need to tell my doctor at the next visit?
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Other interactions of Imatinib
- Imatinib + Lomitapide Contraindicated
- Imatinib + Lonafarnib Contraindicated
- Amobarbital + Imatinib Major
- Apalutamide + Imatinib Major
- Avapritinib + Imatinib Major
- Benzhydrocodone / acetaminophen + Imatinib Major
Other interactions of Crofelemer
- Crofelemer + Ergotamine Moderate
- Alfuzosin + Crofelemer Minor
- Amiodarone + Crofelemer Minor
- Apixaban + Crofelemer Minor
- Aprepitant + Crofelemer Minor
- Armodafinil + Crofelemer Minor
Frequently asked questions
Can I take Crofelemer with Imatinib?
MediHelp rates the interaction as minor. Crofelemer and Imatinib have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised. Crofelemer is minimally absorbed, so systemic interaction with imatinib is unlikely. It may inhibit CYP3A4 and transporters in the gut, but a meaningful change in imatinib exposure has not been demonstrated.
How serious is the interaction between Crofelemer and Imatinib?
MediHelp rates it minor, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: No routine action is needed; monitor for imatinib adverse effects if diarrhea management changes.
What other medicines interact with Imatinib?
MediHelp also lists interactions of Imatinib with, for example, Lomitapide, Lonafarnib, Amobarbital. The full list is on the Imatinib page.
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