Drug interactions
Crofelemer + Nimodipine
Severity: Minor
Crofelemer and Nimodipine: minor interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Crofelemer is minimally absorbed but may inhibit CYP3A4 in the gut. Intestinal first-pass metabolism of oral nimodipine could therefore fall, modestly raising its exposure. Clinical significance is uncertain.
What this interaction means in plain words
Crofelemer and Nimodipine have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised.
Crofelemer belongs to Gastrointestinal Tract; Nimodipine belongs to Cardiovascular.
Why it happens
Possible intestinal CYP3A4 inhibition by crofelemer reduces first-pass metabolism of nimodipine.
What to do
Monitor blood pressure when starting crofelemer in patients on nimodipine. Reduce the nimodipine dose if hypotension occurs.
What to ask your pharmacist
- Is there anything I should notice while taking both?
- Do I need to tell my doctor at the next visit?
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Other interactions of Nimodipine
- Apalutamide + Nimodipine Major
- Carbamazepine + Nimodipine Major
- Ceritinib + Nimodipine Major
- Clarithromycin + Nimodipine Major
- Cobicistat + Nimodipine Major
- Darunavir + Nimodipine Major
Other interactions of Crofelemer
- Crofelemer + Ergotamine Moderate
- Alfuzosin + Crofelemer Minor
- Amiodarone + Crofelemer Minor
- Apixaban + Crofelemer Minor
- Aprepitant + Crofelemer Minor
- Armodafinil + Crofelemer Minor
Frequently asked questions
Can I take Crofelemer with Nimodipine?
MediHelp rates the interaction as minor. Crofelemer and Nimodipine have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised. Crofelemer is minimally absorbed but may inhibit CYP3A4 in the gut. Intestinal first-pass metabolism of oral nimodipine could therefore fall, modestly raising its exposure. Clinical significance is uncertain.
How serious is the interaction between Crofelemer and Nimodipine?
MediHelp rates it minor, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor blood pressure when starting crofelemer in patients on nimodipine. Reduce the nimodipine dose if hypotension occurs.
What other medicines interact with Nimodipine?
MediHelp also lists interactions of Nimodipine with, for example, Apalutamide, Carbamazepine, Ceritinib. The full list is on the Nimodipine page.
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