Drug interactions
Crofelemer + Primaquine
Severity: Minor
Crofelemer and Primaquine: minor interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Crofelemer is minimally absorbed, so systemic CYP3A4 inhibition is unlikely. Only a theoretical gut-level effect exists, and no clinically relevant change in primaquine exposure is expected.
What this interaction means in plain words
Crofelemer and Primaquine have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised.
Crofelemer belongs to Gastrointestinal Tract; Primaquine belongs to Anti Parasitic.
Why it happens
Theoretical intestinal CYP3A4 inhibition by crofelemer; not shown clinically.
What to do
No dose adjustment is needed; monitor for primaquine adverse effects such as gastrointestinal upset or hemolysis as usual.
What to ask your pharmacist
- Is there anything I should notice while taking both?
- Do I need to tell my doctor at the next visit?
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Other interactions of Primaquine
- Pimozide + Primaquine Contraindicated
- Amiodarone + Primaquine Major
- Amisulpride + Primaquine Major
- Anagrelide + Primaquine Major
- Arsenic trioxide + Primaquine Major
- Asenapine + Primaquine Major
Other interactions of Crofelemer
- Crofelemer + Ergotamine Moderate
- Alfuzosin + Crofelemer Minor
- Amiodarone + Crofelemer Minor
- Apixaban + Crofelemer Minor
- Aprepitant + Crofelemer Minor
- Armodafinil + Crofelemer Minor
Frequently asked questions
Can I take Crofelemer with Primaquine?
MediHelp rates the interaction as minor. Crofelemer and Primaquine have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised. Crofelemer is minimally absorbed, so systemic CYP3A4 inhibition is unlikely. Only a theoretical gut-level effect exists, and no clinically relevant change in primaquine exposure is expected.
How serious is the interaction between Crofelemer and Primaquine?
MediHelp rates it minor, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: No dose adjustment is needed; monitor for primaquine adverse effects such as gastrointestinal upset or hemolysis as usual.
What other medicines interact with Primaquine?
MediHelp also lists interactions of Primaquine with, for example, Pimozide, Amiodarone, Amisulpride. The full list is on the Primaquine page.
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