Drug interactions
Crofelemer + Quetiapine
Severity: Minor
Crofelemer and Quetiapine: minor interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Crofelemer is minimally absorbed and inhibits CYP3A4 only in the gut in vitro. A clinically relevant increase in quetiapine exposure is unlikely.
What this interaction means in plain words
Crofelemer and Quetiapine have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised.
Crofelemer belongs to Gastrointestinal Tract; Quetiapine belongs to Central Nervous System.
Why it happens
Possible intestinal CYP3A4 inhibition in the gut lumen, with negligible systemic effect.
What to do
No routine adjustment is needed. Monitor for sedation or hypotension if the patient is sensitive to quetiapine.
What to ask your pharmacist
- Is there anything I should notice while taking both?
- Do I need to tell my doctor at the next visit?
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Other interactions of Quetiapine
- Adagrasib + Quetiapine Major
- Amiodarone + Quetiapine Major
- Amisulpride + Quetiapine Major
- Amoxapine + Quetiapine Major
- Anagrelide + Quetiapine Major
- Apalutamide + Quetiapine Major
Other interactions of Crofelemer
- Crofelemer + Ergotamine Moderate
- Alfuzosin + Crofelemer Minor
- Amiodarone + Crofelemer Minor
- Apixaban + Crofelemer Minor
- Aprepitant + Crofelemer Minor
- Armodafinil + Crofelemer Minor
Frequently asked questions
Can I take Crofelemer with Quetiapine?
MediHelp rates the interaction as minor. Crofelemer and Quetiapine have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised. Crofelemer is minimally absorbed and inhibits CYP3A4 only in the gut in vitro. A clinically relevant increase in quetiapine exposure is unlikely.
How serious is the interaction between Crofelemer and Quetiapine?
MediHelp rates it minor, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: No routine adjustment is needed. Monitor for sedation or hypotension if the patient is sensitive to quetiapine.
What other medicines interact with Quetiapine?
MediHelp also lists interactions of Quetiapine with, for example, Adagrasib, Amiodarone, Amisulpride. The full list is on the Quetiapine page.
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