Drug interactions
Crofelemer + Rosuvastatin
Severity: Minor
Crofelemer and Rosuvastatin: minor interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Crofelemer is minimally absorbed and acts locally in the gut, where it may inhibit transporters involved in rosuvastatin handling. A clinically relevant systemic interaction is unlikely.
What this interaction means in plain words
Crofelemer and Rosuvastatin have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised.
Crofelemer belongs to Gastrointestinal Tract; Rosuvastatin belongs to Cardiovascular.
Why it happens
Crofelemer may inhibit intestinal MRP2 and OATP1A2 transporters, though systemic inhibition is not expected.
What to do
No dose adjustment is needed; monitor for muscle symptoms as part of routine statin care.
What to ask your pharmacist
- Is there anything I should notice while taking both?
- Do I need to tell my doctor at the next visit?
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Other interactions of Rosuvastatin
Other interactions of Crofelemer
- Crofelemer + Ergotamine Moderate
- Alfuzosin + Crofelemer Minor
- Amiodarone + Crofelemer Minor
- Apixaban + Crofelemer Minor
- Aprepitant + Crofelemer Minor
- Armodafinil + Crofelemer Minor
Frequently asked questions
Can I take Crofelemer with Rosuvastatin?
MediHelp rates the interaction as minor. Crofelemer and Rosuvastatin have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised. Crofelemer is minimally absorbed and acts locally in the gut, where it may inhibit transporters involved in rosuvastatin handling. A clinically relevant systemic interaction is unlikely.
How serious is the interaction between Crofelemer and Rosuvastatin?
MediHelp rates it minor, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: No dose adjustment is needed; monitor for muscle symptoms as part of routine statin care.
What other medicines interact with Rosuvastatin?
MediHelp also lists interactions of Rosuvastatin with, for example, Atazanavir, Cyclosporin, Darolutamide. The full list is on the Rosuvastatin page.
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