Drug interactions
Crofelemer + Tamsulosin
Severity: Minor
Crofelemer and Tamsulosin: minor interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Crofelemer may inhibit CYP3A4 in the gut but is minimally absorbed. A clinically relevant rise in tamsulosin levels is unlikely.
What this interaction means in plain words
Crofelemer and Tamsulosin have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised.
Crofelemer belongs to Gastrointestinal Tract; Tamsulosin belongs to Genitourinary.
Why it happens
Possible intestinal CYP3A4 inhibition with minimal systemic effect.
What to do
No action is generally needed. Monitor for dizziness or hypotension if symptoms occur.
What to ask your pharmacist
- Is there anything I should notice while taking both?
- Do I need to tell my doctor at the next visit?
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Other interactions of Tamsulosin
- Alfuzosin + Tamsulosin Major
- Avanafil + Tamsulosin Major
- Ceritinib + Tamsulosin Major
- Clarithromycin + Tamsulosin Major
- Cobicistat + Tamsulosin Major
- Doxazosin + Tamsulosin Major
Other interactions of Crofelemer
- Crofelemer + Ergotamine Moderate
- Alfuzosin + Crofelemer Minor
- Amiodarone + Crofelemer Minor
- Apixaban + Crofelemer Minor
- Aprepitant + Crofelemer Minor
- Armodafinil + Crofelemer Minor
Frequently asked questions
Can I take Crofelemer with Tamsulosin?
MediHelp rates the interaction as minor. Crofelemer and Tamsulosin have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised. Crofelemer may inhibit CYP3A4 in the gut but is minimally absorbed. A clinically relevant rise in tamsulosin levels is unlikely.
How serious is the interaction between Crofelemer and Tamsulosin?
MediHelp rates it minor, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: No action is generally needed. Monitor for dizziness or hypotension if symptoms occur.
What other medicines interact with Tamsulosin?
MediHelp also lists interactions of Tamsulosin with, for example, Alfuzosin, Avanafil, Ceritinib. The full list is on the Tamsulosin page.
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