Drug interactions
Crofelemer + Verapamil
Severity: Minor
Crofelemer and Verapamil: minor interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Crofelemer is minimally absorbed, so its CYP3A4 inhibition is confined mainly to the gut. A meaningful rise in verapamil exposure is therefore unlikely, although a small intestinal effect cannot be excluded.
What this interaction means in plain words
Crofelemer and Verapamil have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised.
Crofelemer belongs to Gastrointestinal Tract; Verapamil belongs to Cardiovascular.
Why it happens
Crofelemer may inhibit intestinal CYP3A4 in vitro at gut concentrations, with negligible systemic exposure.
What to do
No dose change is generally required; monitor heart rate and blood pressure if verapamil effects seem exaggerated.
What to ask your pharmacist
- Is there anything I should notice while taking both?
- Do I need to tell my doctor at the next visit?
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Other interactions of Verapamil
- Dofetilide + Verapamil Contraindicated
- Flibanserin + Verapamil Contraindicated
- Lomitapide + Verapamil Contraindicated
- Lonafarnib + Verapamil Contraindicated
- Pimozide + Verapamil Contraindicated
- Acebutolol + Verapamil Major
Other interactions of Crofelemer
- Crofelemer + Ergotamine Moderate
- Alfuzosin + Crofelemer Minor
- Amiodarone + Crofelemer Minor
- Apixaban + Crofelemer Minor
- Aprepitant + Crofelemer Minor
- Armodafinil + Crofelemer Minor
Frequently asked questions
Can I take Crofelemer with Verapamil?
MediHelp rates the interaction as minor. Crofelemer and Verapamil have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised. Crofelemer is minimally absorbed, so its CYP3A4 inhibition is confined mainly to the gut. A meaningful rise in verapamil exposure is therefore unlikely, although a small intestinal effect cannot be excluded.
How serious is the interaction between Crofelemer and Verapamil?
MediHelp rates it minor, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: No dose change is generally required; monitor heart rate and blood pressure if verapamil effects seem exaggerated.
What other medicines interact with Verapamil?
MediHelp also lists interactions of Verapamil with, for example, Dofetilide, Flibanserin, Lomitapide. The full list is on the Verapamil page.
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