Drug interactions
Cyclizine + Dantrolene
Severity: Moderate
Cyclizine and Dantrolene: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Cyclizine is a sedating antihistamine and dantrolene frequently causes drowsiness. Used together they may produce more pronounced sedation and reduced alertness.
What this interaction means in plain words
Cyclizine and Dantrolene can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Cyclizine belongs to Respiratory; Dantrolene belongs to Musculoskeletal.
Why it happens
Additive central nervous system depression via H1-antihistamine sedation and dantrolene's sedative effects.
What to do
Monitor for excess drowsiness and warn patients against driving or operating machinery. Consider a non-sedating alternative to cyclizine if sedation is a problem.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Dantrolene
Other interactions of Cyclizine
- Calcium / magnesium / potassium / sodium oxybates + Cyclizine Major
- Cyclizine + Henbane Major
- Cyclizine + Sodium oxybate Major
- Abobotulinumtoxina + Cyclizine Moderate
- Alfentanil + Cyclizine Moderate
- Alprazolam + Cyclizine Moderate
Frequently asked questions
Can I take Cyclizine with Dantrolene?
MediHelp rates the interaction as moderate. Cyclizine and Dantrolene can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Cyclizine is a sedating antihistamine and dantrolene frequently causes drowsiness. Used together they may produce more pronounced sedation and reduced alertness.
How serious is the interaction between Cyclizine and Dantrolene?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor for excess drowsiness and warn patients against driving or operating machinery. Consider a non-sedating alternative to cyclizine if sedation is a problem.
What other medicines interact with Dantrolene?
MediHelp also lists interactions of Dantrolene with, for example, Benzhydrocodone / acetaminophen, Buprenorphine long-acting, Buprenorphine subdermal implant. The full list is on the Dantrolene page.
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