Drug interactions
Cyclizine + Fenfluramine
Severity: Minor
Cyclizine and Fenfluramine: minor interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Cyclizine causes sedation, while fenfluramine is a serotonergic agent, now used for seizures in Dravet syndrome, that can cause somnolence or fatigue. Fenfluramine can also cause somnolence, so any combined effect on alertness is unpredictable, and no established interaction exists.
What this interaction means in plain words
Cyclizine and Fenfluramine have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised.
Cyclizine belongs to Respiratory; Fenfluramine belongs to Central Nervous System.
Why it happens
No established mechanism; possible additive CNS effects.
What to do
Monitor for excessive drowsiness and counsel on driving.
What to ask your pharmacist
- Is there anything I should notice while taking both?
- Do I need to tell my doctor at the next visit?
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Other interactions of Cyclizine
- Calcium / magnesium / potassium / sodium oxybates + Cyclizine Major
- Cyclizine + Henbane Major
- Cyclizine + Sodium oxybate Major
- Abobotulinumtoxina + Cyclizine Moderate
- Alfentanil + Cyclizine Moderate
- Alprazolam + Cyclizine Moderate
Other interactions of Fenfluramine
- Fenfluramine + Isocarboxazid Contraindicated
- Fenfluramine + Linezolid Contraindicated
- Fenfluramine + Phenelzine Contraindicated
- Fenfluramine + Selegiline Contraindicated
- Fenfluramine + Tranylcypromine Contraindicated
- Almotriptan + Fenfluramine Major
Frequently asked questions
Can I take Cyclizine with Fenfluramine?
MediHelp rates the interaction as minor. Cyclizine and Fenfluramine have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised. Cyclizine causes sedation, while fenfluramine is a serotonergic agent, now used for seizures in Dravet syndrome, that can cause somnolence or fatigue. Fenfluramine can also cause somnolence, so any combined effect on alertness is unpredictable, and no established interaction exists.
How serious is the interaction between Cyclizine and Fenfluramine?
MediHelp rates it minor, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor for excessive drowsiness and counsel on driving.
What other medicines interact with Cyclizine?
MediHelp also lists interactions of Cyclizine with, for example, Calcium / magnesium / potassium / sodium oxybates, Henbane, Sodium oxybate. The full list is on the Cyclizine page.
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