Drug interactions
Cyclobenzaprine + Metoclopramide
Severity: Moderate
Cyclobenzaprine and Metoclopramide: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Cyclobenzaprine is structurally related to tricyclic antidepressants and is sedating and anticholinergic. With metoclopramide, there may be increased sedation and a possible increased risk of serotonin syndrome or extrapyramidal effects; anticholinergic effects may also oppose metoclopramide's prokinetic action.
What this interaction means in plain words
Cyclobenzaprine and Metoclopramide can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Cyclobenzaprine belongs to Musculoskeletal; Metoclopramide belongs to Gastrointestinal Tract.
Why it happens
Additive central nervous system depression and serotonergic effects, with anticholinergic antagonism of prokinetic action.
What to do
Monitor for sedation, agitation, tremor and rigidity. Use the lowest effective doses and limit duration.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
Pro+ members
Unlock the full page
Create an account and start a Pro+ trial to unlock the full management advice for Cyclobenzaprine and Metoclopramide, the additional notes, the evidence detail and the whole-prescription interaction checker.
- Full clinical management advice
- Additional notes
- Evidence detail
- Interaction checker for a whole prescription
Try Pro+ free for 7 days on the web. No card needed.
Other interactions of Metoclopramide
Other interactions of Cyclobenzaprine
- Cyclobenzaprine + Isocarboxazid Contraindicated
- Cyclobenzaprine + Linezolid Contraindicated
- Cyclobenzaprine + Phenelzine Contraindicated
- Cyclobenzaprine + Safinamide Contraindicated
- Cyclobenzaprine + Selegiline Contraindicated
- Cyclobenzaprine + Selegiline transdermal Contraindicated
Frequently asked questions
Can I take Cyclobenzaprine with Metoclopramide?
MediHelp rates the interaction as moderate. Cyclobenzaprine and Metoclopramide can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Cyclobenzaprine is structurally related to tricyclic antidepressants and is sedating and anticholinergic. With metoclopramide, there may be increased sedation and a possible increased risk of serotonin syndrome or extrapyramidal effects; anticholinergic effects may also oppose metoclopramide's prokinetic action.
How serious is the interaction between Cyclobenzaprine and Metoclopramide?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor for sedation, agitation, tremor and rigidity. Use the lowest effective doses and limit duration.
What other medicines interact with Metoclopramide?
MediHelp also lists interactions of Metoclopramide with, for example, Amantadine, Amoxapine, Antipsychotics (e.g., haloperidol). The full list is on the Metoclopramide page.
Full monographs, dosing and an interaction checker in the MediHelp app
Open the complete reference, check multi-drug interactions and use dosing tools in the MediHelp app.
