Drug interactions
Cyclobenzaprine + Propofol
Severity: Moderate
Cyclobenzaprine and Propofol: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Propofol is a potent sedative-hypnotic and cyclobenzaprine adds sedative effect, so anaesthetic requirements may be reduced and respiratory or cardiovascular depression may be more pronounced. This is usually manageable in a monitored setting.
What this interaction means in plain words
Cyclobenzaprine and Propofol can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Cyclobenzaprine belongs to Musculoskeletal; Propofol belongs to Central Nervous System.
Why it happens
Additive CNS depression.
What to do
Titrate propofol to effect with continuous monitoring of ventilation and blood pressure. Tell the anaesthesia team about recent cyclobenzaprine use.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Cyclobenzaprine
- Cyclobenzaprine + Isocarboxazid Contraindicated
- Cyclobenzaprine + Linezolid Contraindicated
- Cyclobenzaprine + Phenelzine Contraindicated
- Cyclobenzaprine + Safinamide Contraindicated
- Cyclobenzaprine + Selegiline Contraindicated
- Cyclobenzaprine + Selegiline transdermal Contraindicated
Other interactions of Propofol
Frequently asked questions
Can I take Cyclobenzaprine with Propofol?
MediHelp rates the interaction as moderate. Cyclobenzaprine and Propofol can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Propofol is a potent sedative-hypnotic and cyclobenzaprine adds sedative effect, so anaesthetic requirements may be reduced and respiratory or cardiovascular depression may be more pronounced. This is usually manageable in a monitored setting.
How serious is the interaction between Cyclobenzaprine and Propofol?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Titrate propofol to effect with continuous monitoring of ventilation and blood pressure. Tell the anaesthesia team about recent cyclobenzaprine use.
What other medicines interact with Cyclobenzaprine?
MediHelp also lists interactions of Cyclobenzaprine with, for example, Isocarboxazid, Linezolid, Phenelzine. The full list is on the Cyclobenzaprine page.
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