Drug interactions
Cyclobenzaprine + Teriflunomide
Severity: Minor
Cyclobenzaprine and Teriflunomide: minor interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Teriflunomide is a weak inducer of CYP1A2, a pathway involved in cyclobenzaprine metabolism, so cyclobenzaprine exposure may fall slightly. The effect is expected to be small and clinical impact limited.
What this interaction means in plain words
Cyclobenzaprine and Teriflunomide have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised.
Cyclobenzaprine belongs to Musculoskeletal; Teriflunomide belongs to Central Nervous System.
Why it happens
Weak CYP1A2 induction by teriflunomide increases cyclobenzaprine metabolism.
What to do
No empiric dose change is needed. Monitor for reduced muscle relaxant effect and adjust the dose if needed.
What to ask your pharmacist
- Is there anything I should notice while taking both?
- Do I need to tell my doctor at the next visit?
Pro+ members
Unlock the full page
Create an account and start a Pro+ trial to unlock the full management advice for Cyclobenzaprine and Teriflunomide, the additional notes, the evidence detail and the whole-prescription interaction checker.
- Full clinical management advice
- Additional notes
- Evidence detail
- Interaction checker for a whole prescription
Try Pro+ free for 7 days on the web. No card needed.
Other interactions of Cyclobenzaprine
- Cyclobenzaprine + Isocarboxazid Contraindicated
- Cyclobenzaprine + Linezolid Contraindicated
- Cyclobenzaprine + Phenelzine Contraindicated
- Cyclobenzaprine + Safinamide Contraindicated
- Cyclobenzaprine + Selegiline Contraindicated
- Cyclobenzaprine + Selegiline transdermal Contraindicated
Other interactions of Teriflunomide
Frequently asked questions
Can I take Cyclobenzaprine with Teriflunomide?
MediHelp rates the interaction as minor. Cyclobenzaprine and Teriflunomide have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised. Teriflunomide is a weak inducer of CYP1A2, a pathway involved in cyclobenzaprine metabolism, so cyclobenzaprine exposure may fall slightly. The effect is expected to be small and clinical impact limited.
How serious is the interaction between Cyclobenzaprine and Teriflunomide?
MediHelp rates it minor, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: No empiric dose change is needed. Monitor for reduced muscle relaxant effect and adjust the dose if needed.
What other medicines interact with Cyclobenzaprine?
MediHelp also lists interactions of Cyclobenzaprine with, for example, Isocarboxazid, Linezolid, Phenelzine. The full list is on the Cyclobenzaprine page.
Full monographs, dosing and an interaction checker in the MediHelp app
Open the complete reference, check multi-drug interactions and use dosing tools in the MediHelp app.
