Drug interactions
Cyclophosphamide + Elagolix
Severity: Minor
Cyclophosphamide and Elagolix: minor interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Elagolix is a weak-to-moderate CYP3A4 inducer, which may slightly change cyclophosphamide metabolism. Cyclophosphamide relies only partly on CYP3A4, and elagolix is not usually used with chemotherapy. Clinical relevance is likely low.
What this interaction means in plain words
Cyclophosphamide and Elagolix have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised.
Cyclophosphamide belongs to Oncology; Elagolix belongs to Musculoskeletal.
Why it happens
CYP3A4 induction by elagolix may modestly alter cyclophosphamide metabolism.
What to do
No dose adjustment is generally needed. Monitor treatment response and toxicity.
What to ask your pharmacist
- Is there anything I should notice while taking both?
- Do I need to tell my doctor at the next visit?
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Other interactions of Cyclophosphamide
Other interactions of Elagolix
- Cyclosporin + Elagolix Contraindicated
- Elagolix + Gemfibrozil Contraindicated
- Desogestrel-ethinyl estradiol + Elagolix Major
- Elagolix + Erythromycin Major
- Elagolix + Ethinyl estradiol-drospirenone Major
- Elagolix + Ethinyl estradiol-levonorgestrel Major
Frequently asked questions
Can I take Cyclophosphamide with Elagolix?
MediHelp rates the interaction as minor. Cyclophosphamide and Elagolix have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised. Elagolix is a weak-to-moderate CYP3A4 inducer, which may slightly change cyclophosphamide metabolism. Cyclophosphamide relies only partly on CYP3A4, and elagolix is not usually used with chemotherapy. Clinical relevance is likely low.
How serious is the interaction between Cyclophosphamide and Elagolix?
MediHelp rates it minor, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: No dose adjustment is generally needed. Monitor treatment response and toxicity.
What other medicines interact with Cyclophosphamide?
MediHelp also lists interactions of Cyclophosphamide with, for example, Adenovirus types 4 and 7 live, Belatacept, Bendamustine. The full list is on the Cyclophosphamide page.
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