Drug interactions
Cyclosporin + Disopyramide
Severity: Moderate
Cyclosporin and Disopyramide: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Cyclosporine may raise disopyramide levels, increasing the risk of anticholinergic effects and proarrhythmia including QT prolongation. Disopyramide may also affect cyclosporine kinetics in some reports.
What this interaction means in plain words
Cyclosporin and Disopyramide can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Cyclosporin belongs to Miscellaneous; Disopyramide belongs to Cardiovascular.
Why it happens
Cyclosporine inhibits CYP3A4-mediated N-dealkylation of disopyramide.
What to do
Monitor ECG and disopyramide levels and reduce the dose if QT prolongation or anticholinergic effects appear.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Cyclosporin
- Adenovirus types 4 and 7 live + Cyclosporin Contraindicated
- Aliskiren + Cyclosporin Contraindicated
- Bcg vaccine live + Cyclosporin Contraindicated
- Bosentan + Cyclosporin Contraindicated
- Cidofovir + Cyclosporin Contraindicated
- Cyclosporin + Dengue vaccine Contraindicated
Other interactions of Disopyramide
- Amisulpride + Disopyramide Contraindicated
- Desipramine + Disopyramide Contraindicated
- Disopyramide + Dronedarone Contraindicated
- Disopyramide + Itraconazole Contraindicated
- Disopyramide + Ketoconazole Contraindicated
- Disopyramide + Maprotiline Contraindicated
Frequently asked questions
Can I take Cyclosporin with Disopyramide?
MediHelp rates the interaction as moderate. Cyclosporin and Disopyramide can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Cyclosporine may raise disopyramide levels, increasing the risk of anticholinergic effects and proarrhythmia including QT prolongation. Disopyramide may also affect cyclosporine kinetics in some reports.
How serious is the interaction between Cyclosporin and Disopyramide?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor ECG and disopyramide levels and reduce the dose if QT prolongation or anticholinergic effects appear.
What other medicines interact with Cyclosporin?
MediHelp also lists interactions of Cyclosporin with, for example, Adenovirus types 4 and 7 live, Aliskiren, Bcg vaccine live. The full list is on the Cyclosporin page.
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