Drug interactions
Cyclosporin + Fenofibric acid
Severity: Moderate
Cyclosporin and Fenofibric acid: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Fibrates have been associated with reversible rises in serum creatinine in patients on cyclosporine, and cyclosporine exposure may also change. The renal effect can be mistaken for graft or cyclosporine toxicity.
What this interaction means in plain words
Cyclosporin and Fenofibric acid can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Cyclosporin belongs to Miscellaneous; Fenofibric acid belongs to Cardiovascular.
Why it happens
Mechanism is not firmly established; additive effects on renal hemodynamics and possible changes in cyclosporine disposition are proposed.
What to do
Monitor serum creatinine and cyclosporine trough levels after starting or stopping fenofibric acid. Stop the fibrate if renal function worsens.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
Pro+ members
Unlock the full page
Create an account and start a Pro+ trial to unlock the full management advice for Cyclosporin and Fenofibric acid, the additional notes, the evidence detail and the whole-prescription interaction checker.
- Full clinical management advice
- Additional notes
- Evidence detail
- Interaction checker for a whole prescription
Try Pro+ free for 7 days on the web. No card needed.
Other interactions of Cyclosporin
- Adenovirus types 4 and 7 live + Cyclosporin Contraindicated
- Aliskiren + Cyclosporin Contraindicated
- Bcg vaccine live + Cyclosporin Contraindicated
- Bosentan + Cyclosporin Contraindicated
- Cidofovir + Cyclosporin Contraindicated
- Cyclosporin + Dengue vaccine Contraindicated
Other interactions of Fenofibric acid
- Atorvastatin + Fenofibric acid Moderate
- Chlorpropamide + Fenofibric acid Moderate
- Cholestyramine + Fenofibric acid Moderate
- Cholic acid + Fenofibric acid Moderate
- Colchicine + Fenofibric acid Moderate
- Colestipol + Fenofibric acid Moderate
Frequently asked questions
Can I take Cyclosporin with Fenofibric acid?
MediHelp rates the interaction as moderate. Cyclosporin and Fenofibric acid can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Fibrates have been associated with reversible rises in serum creatinine in patients on cyclosporine, and cyclosporine exposure may also change. The renal effect can be mistaken for graft or cyclosporine toxicity.
How serious is the interaction between Cyclosporin and Fenofibric acid?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor serum creatinine and cyclosporine trough levels after starting or stopping fenofibric acid. Stop the fibrate if renal function worsens.
What other medicines interact with Cyclosporin?
MediHelp also lists interactions of Cyclosporin with, for example, Adenovirus types 4 and 7 live, Aliskiren, Bcg vaccine live. The full list is on the Cyclosporin page.
Full monographs, dosing and an interaction checker in the MediHelp app
Open the complete reference, check multi-drug interactions and use dosing tools in the MediHelp app.
