Drug interactions
Cyclosporin + Maraviroc
Severity: Moderate
Cyclosporin and Maraviroc: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Maraviroc is a CYP3A4 and P-gp substrate, and cyclosporine can raise its concentrations. This may increase adverse effects such as postural hypotension and hepatotoxicity.
What this interaction means in plain words
Cyclosporin and Maraviroc can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Cyclosporin belongs to Miscellaneous; Maraviroc belongs to Anti Virals.
Why it happens
Cyclosporine inhibits CYP3A4 and P-glycoprotein, reducing maraviroc clearance.
What to do
Monitor for maraviroc adverse effects, including blood pressure and liver function, and consider dose reduction guided by the maraviroc label for CYP3A inhibitors.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Cyclosporin
- Adenovirus types 4 and 7 live + Cyclosporin Contraindicated
- Aliskiren + Cyclosporin Contraindicated
- Bcg vaccine live + Cyclosporin Contraindicated
- Bosentan + Cyclosporin Contraindicated
- Cidofovir + Cyclosporin Contraindicated
- Cyclosporin + Dengue vaccine Contraindicated
Other interactions of Maraviroc
- Amobarbital + Maraviroc Major
- Apalutamide + Maraviroc Major
- Carbamazepine + Maraviroc Major
- Clarithromycin + Maraviroc Major
- Efavirenz + Maraviroc Major
- Enzalutamide + Maraviroc Major
Frequently asked questions
Can I take Cyclosporin with Maraviroc?
MediHelp rates the interaction as moderate. Cyclosporin and Maraviroc can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Maraviroc is a CYP3A4 and P-gp substrate, and cyclosporine can raise its concentrations. This may increase adverse effects such as postural hypotension and hepatotoxicity.
How serious is the interaction between Cyclosporin and Maraviroc?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor for maraviroc adverse effects, including blood pressure and liver function, and consider dose reduction guided by the maraviroc label for CYP3A inhibitors.
What other medicines interact with Cyclosporin?
MediHelp also lists interactions of Cyclosporin with, for example, Adenovirus types 4 and 7 live, Aliskiren, Bcg vaccine live. The full list is on the Cyclosporin page.
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