Drug interactions
Cyclosporin + Metoclopramide
Severity: Moderate
Cyclosporin and Metoclopramide: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Metoclopramide can increase oral cyclosporine absorption and raise blood concentrations. This may increase the risk of cyclosporine toxicity.
What this interaction means in plain words
Cyclosporin and Metoclopramide can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Cyclosporin belongs to Miscellaneous; Metoclopramide belongs to Gastrointestinal Tract.
Why it happens
Accelerated gastric emptying increases the rate and extent of oral cyclosporine absorption.
What to do
Monitor cyclosporine trough levels when metoclopramide is started or stopped and adjust the cyclosporine dose. Watch renal function and blood pressure.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Cyclosporin
- Adenovirus types 4 and 7 live + Cyclosporin Contraindicated
- Aliskiren + Cyclosporin Contraindicated
- Bcg vaccine live + Cyclosporin Contraindicated
- Bosentan + Cyclosporin Contraindicated
- Cidofovir + Cyclosporin Contraindicated
- Cyclosporin + Dengue vaccine Contraindicated
Other interactions of Metoclopramide
Frequently asked questions
Can I take Cyclosporin with Metoclopramide?
MediHelp rates the interaction as moderate. Cyclosporin and Metoclopramide can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Metoclopramide can increase oral cyclosporine absorption and raise blood concentrations. This may increase the risk of cyclosporine toxicity.
How serious is the interaction between Cyclosporin and Metoclopramide?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor cyclosporine trough levels when metoclopramide is started or stopped and adjust the cyclosporine dose. Watch renal function and blood pressure.
What other medicines interact with Cyclosporin?
MediHelp also lists interactions of Cyclosporin with, for example, Adenovirus types 4 and 7 live, Aliskiren, Bcg vaccine live. The full list is on the Cyclosporin page.
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