Drug interactions
Gemfibrozil + Momelotinib
Severity: Moderate
Gemfibrozil and Momelotinib: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Gemfibrozil may raise momelotinib plasma concentrations by impairing its hepatic uptake. This may increase momelotinib adverse reactions such as cytopenias, hepatotoxicity and gastrointestinal effects.
What this interaction means in plain words
Gemfibrozil and Momelotinib can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Gemfibrozil belongs to Cardiovascular; Momelotinib belongs to Oncology.
Why it happens
Inhibition of OATP1B1/1B3 transporters by gemfibrozil, reducing hepatic uptake of momelotinib.
What to do
Monitor blood counts, liver tests and tolerability; consider an alternative lipid-lowering drug if adverse effects emerge.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Gemfibrozil
- Daprodustat + Gemfibrozil Contraindicated
- Elagolix + Gemfibrozil Contraindicated
- Gemfibrozil + Mavacamten Contraindicated
- Gemfibrozil + Metformin-repaglinide Contraindicated
- Gemfibrozil + Ombitasvir / paritaprevir / ritonavir and dasabuvir Contraindicated
- Gemfibrozil + Repaglinide Contraindicated
Other interactions of Momelotinib
- Atorvastatin + Momelotinib Moderate
- Clarithromycin + Momelotinib Moderate
- Cyclosporin + Momelotinib Moderate
- Daunorubicin + Momelotinib Moderate
- Erythromycin + Momelotinib Moderate
- Fluvastatin + Momelotinib Moderate
Frequently asked questions
Can I take Gemfibrozil with Momelotinib?
MediHelp rates the interaction as moderate. Gemfibrozil and Momelotinib can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Gemfibrozil may raise momelotinib plasma concentrations by impairing its hepatic uptake. This may increase momelotinib adverse reactions such as cytopenias, hepatotoxicity and gastrointestinal effects.
How serious is the interaction between Gemfibrozil and Momelotinib?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor blood counts, liver tests and tolerability; consider an alternative lipid-lowering drug if adverse effects emerge.
What other medicines interact with Gemfibrozil?
MediHelp also lists interactions of Gemfibrozil with, for example, Daprodustat, Elagolix, Mavacamten. The full list is on the Gemfibrozil page.
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