Drug interactions
Cyclosporin + Montelukast
Severity: Minor
Cyclosporin and Montelukast: minor interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Cyclosporine may modestly increase montelukast exposure, but montelukast is metabolized by several pathways and CYP3A4 is not dominant. Clinically significant changes are not expected given montelukast's wide therapeutic margin.
What this interaction means in plain words
Cyclosporin and Montelukast have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised.
Cyclosporin belongs to Miscellaneous; Montelukast belongs to Respiratory.
Why it happens
Possible CYP3A4 and transporter inhibition by cyclosporine, which has a minor role in montelukast clearance.
What to do
No dose adjustment is usually needed; monitor for increased montelukast adverse effects such as headache or neuropsychiatric symptoms.
What to ask your pharmacist
- Is there anything I should notice while taking both?
- Do I need to tell my doctor at the next visit?
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Other interactions of Cyclosporin
- Adenovirus types 4 and 7 live + Cyclosporin Contraindicated
- Aliskiren + Cyclosporin Contraindicated
- Bcg vaccine live + Cyclosporin Contraindicated
- Bosentan + Cyclosporin Contraindicated
- Cidofovir + Cyclosporin Contraindicated
- Cyclosporin + Dengue vaccine Contraindicated
Other interactions of Montelukast
- Apalutamide + Montelukast Moderate
- Carbamazepine + Montelukast Moderate
- Deferasirox + Montelukast Moderate
- Enzalutamide + Montelukast Moderate
- Fosphenytoin + Montelukast Moderate
- Gemfibrozil + Montelukast Moderate
Frequently asked questions
Can I take Cyclosporin with Montelukast?
MediHelp rates the interaction as minor. Cyclosporin and Montelukast have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised. Cyclosporine may modestly increase montelukast exposure, but montelukast is metabolized by several pathways and CYP3A4 is not dominant. Clinically significant changes are not expected given montelukast's wide therapeutic margin.
How serious is the interaction between Cyclosporin and Montelukast?
MediHelp rates it minor, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: No dose adjustment is usually needed; monitor for increased montelukast adverse effects such as headache or neuropsychiatric symptoms.
What other medicines interact with Cyclosporin?
MediHelp also lists interactions of Cyclosporin with, for example, Adenovirus types 4 and 7 live, Aliskiren, Bcg vaccine live. The full list is on the Cyclosporin page.
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