Drug interactions
Cyclosporin + Pacritinib
Severity: Major
Cyclosporin and Pacritinib: major interaction.
Last updated Sources: US FDA label
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Pacritinib is a CYP3A4 substrate, and cyclosporine may raise its levels. Pacritinib may also affect cyclosporine concentrations, and both effects make the combination hard to control.
What this interaction means in plain words
Cyclosporin and Pacritinib can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for.
Cyclosporin belongs to Miscellaneous; Pacritinib belongs to Oncology.
Why it happens
Competing CYP3A4 metabolism and inhibition, with uncertain effects on both drugs.
What to do
Avoid if possible. If used, monitor cyclosporine trough levels and watch for pacritinib toxicity such as bleeding, diarrhea and QT prolongation.
What to ask your pharmacist
- Does the benefit of taking both outweigh the risk in my case?
- Do I need any blood test, ECG or other check while on both?
- What early warning signs should I watch for, and what should I do if they appear?
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References
Other interactions of Cyclosporin
- Adenovirus types 4 and 7 live + Cyclosporin Contraindicated
- Aliskiren + Cyclosporin Contraindicated
- Bcg vaccine live + Cyclosporin Contraindicated
- Bosentan + Cyclosporin Contraindicated
- Cidofovir + Cyclosporin Contraindicated
- Cyclosporin + Dengue vaccine Contraindicated
Other interactions of Pacritinib
- Clarithromycin + Pacritinib Contraindicated
- Ketoconazole + Pacritinib Contraindicated
- Pacritinib + Posaconazole Contraindicated
- Pacritinib + Voriconazole Contraindicated
- Amiodarone + Pacritinib Major
- Carbamazepine + Pacritinib Major
Frequently asked questions
Can I take Cyclosporin with Pacritinib?
MediHelp rates the interaction as major. Cyclosporin and Pacritinib can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for. Pacritinib is a CYP3A4 substrate, and cyclosporine may raise its levels. Pacritinib may also affect cyclosporine concentrations, and both effects make the combination hard to control.
How serious is the interaction between Cyclosporin and Pacritinib?
MediHelp rates it major, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Avoid if possible. If used, monitor cyclosporine trough levels and watch for pacritinib toxicity such as bleeding, diarrhea and QT prolongation.
What other medicines interact with Cyclosporin?
MediHelp also lists interactions of Cyclosporin with, for example, Adenovirus types 4 and 7 live, Aliskiren, Bcg vaccine live. The full list is on the Cyclosporin page.
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