Drug interactions
Cyclosporin + Secukinumab
Severity: Moderate
Cyclosporin and Secukinumab: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Secukinumab may normalize CYP expression suppressed by chronic inflammation, which could slightly lower cyclosporine levels. Clinical significance is uncertain, but the combined immunosuppression may also raise infection risk.
What this interaction means in plain words
Cyclosporin and Secukinumab can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Cyclosporin belongs to Miscellaneous; Secukinumab belongs to Miscellaneous.
Why it happens
Theoretical normalization of CYP450 activity after reduction of inflammatory cytokines; no direct interaction is established.
What to do
Monitor cyclosporine levels and clinical response when starting or stopping secukinumab, and watch for infections.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Cyclosporin
- Adenovirus types 4 and 7 live + Cyclosporin Contraindicated
- Aliskiren + Cyclosporin Contraindicated
- Bcg vaccine live + Cyclosporin Contraindicated
- Bosentan + Cyclosporin Contraindicated
- Cidofovir + Cyclosporin Contraindicated
- Cyclosporin + Dengue vaccine Contraindicated
Other interactions of Secukinumab
- Adenovirus types 4 and 7 live + Secukinumab Major
- Bcg vaccine live + Secukinumab Major
- Influenza virus vaccine quadrivalent intranasal + Secukinumab Major
- Measles mumps and rubella vaccine live + Secukinumab Major
- Measles mumps and rubella vaccine + Secukinumab Major
- Measles mumps rubella and varicella vaccine live + Secukinumab Major
Frequently asked questions
Can I take Cyclosporin with Secukinumab?
MediHelp rates the interaction as moderate. Cyclosporin and Secukinumab can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Secukinumab may normalize CYP expression suppressed by chronic inflammation, which could slightly lower cyclosporine levels. Clinical significance is uncertain, but the combined immunosuppression may also raise infection risk.
How serious is the interaction between Cyclosporin and Secukinumab?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor cyclosporine levels and clinical response when starting or stopping secukinumab, and watch for infections.
What other medicines interact with Cyclosporin?
MediHelp also lists interactions of Cyclosporin with, for example, Adenovirus types 4 and 7 live, Aliskiren, Bcg vaccine live. The full list is on the Cyclosporin page.
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