Drug interactions
Cyclosporine + Fenofibrate
Severity: Moderate
Cyclosporine and Fenofibrate: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Fibrates given with cyclosporine have been associated with increased serum creatinine and reduced renal function. Cyclosporine may also raise fibrate exposure and the risk of myopathy.
What this interaction means in plain words
Cyclosporine and Fenofibrate can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Why it happens
Likely additive nephrotoxic effects and altered renal or transporter handling; the exact mechanism is not fully established.
What to do
Monitor serum creatinine and cyclosporine levels and watch for muscle symptoms. Stop fenofibrate if renal function worsens.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Fenofibrate
- Atorvastatin + Fenofibrate Moderate
- Cholestyramine + Fenofibrate Moderate
- Cholic acid + Fenofibrate Moderate
- Colchicine + Fenofibrate Moderate
- Colestipol + Fenofibrate Moderate
- Cyclosporin + Fenofibrate Moderate
Frequently asked questions
Can I take Cyclosporine with Fenofibrate?
MediHelp rates the interaction as moderate. Cyclosporine and Fenofibrate can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Fibrates given with cyclosporine have been associated with increased serum creatinine and reduced renal function. Cyclosporine may also raise fibrate exposure and the risk of myopathy.
How serious is the interaction between Cyclosporine and Fenofibrate?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor serum creatinine and cyclosporine levels and watch for muscle symptoms. Stop fenofibrate if renal function worsens.
What other medicines interact with Fenofibrate?
MediHelp also lists interactions of Fenofibrate with, for example, Atorvastatin, Cholestyramine, Cholic acid. The full list is on the Fenofibrate page.
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